Claudia Loetsch
Garvan Institute of Medical Research
7 Papers
2 Citations
Claudia Loetsch is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Biology & Interleukin 4. The author has an hindex of 5, co-authored 6 publications. Previous affiliations of Claudia Loetsch include University of New South Wales.
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Papers
Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells
Rodrigo Vazquez-Lombardi,Claudia Loetsch,Claudia Loetsch,Daniela Zinkl,Jennifer Jackson,Peter R. Schofield,Elissa K. Deenick,Elissa K. Deenick,Cecile King,Cecile King,Tri Giang Phan,Tri Giang Phan,Kylie E. Webster,Kylie E. Webster,Jonathan Sprent,Jonathan Sprent,Daniel Christ,Daniel Christ +17 more
TL;DR: It is reported that efficacy is crucially dependent on depletion of Tregs through Fc-mediated immune effector functions and is provided important guidance for the development of next generation IL-2 therapeutics.
Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity.
Nathan W. Zammit,Nathan W. Zammit,Owen M. Siggs,Owen M. Siggs,Paul Gray,Keisuke Horikawa,David B. Langley,David B. Langley,Stacey N. Walters,Stacey N. Walters,Stephen R. Daley,Stephen R. Daley,Claudia Loetsch,Joanna Warren,Joanna Warren,Jin Yan Yap,Daniele Cultrone,Daniele Cultrone,Amanda J. Russell,Elisabeth K. Malle,Jeanette E. Villanueva,Mark J. Cowley,Mark J. Cowley,Velimir Gayevskiy,Marcel E. Dinger,Marcel E. Dinger,Robert Brink,Robert Brink,David Zahra,David Zahra,Geeta Chaudhri,Gunasegaran Karupiah,Gunasegaran Karupiah,Belinda Whittle,Carla M. Roots,Edward M. Bertram,Michiko Yamada,Yogesh Jeelall,Anselm Enders,Benjamin E. Clifton,Peter D. Mabbitt,Colin J. Jackson,Susan R. Watson,Craig N. Jenne,Craig N. Jenne,Lewis L. Lanier,Tim Wiltshire,Matthew H. Spitzer,Matthew H. Spitzer,Garry P. Nolan,Frank Schmitz,Frank Schmitz,Alan Aderem,Benjamin T. Porebski,Ashley M. Buckle,Derek W. Abbott,John B. Ziegler,Maria E. Craig,Maria E. Craig,Paul Z. Benitez-Aguirre,Juliana Teo,Stuart G. Tangye,Stuart G. Tangye,Cecile King,Cecile King,Melanie Wong,Murray P. Cox,Wilson Phung,Jia Tang,Wendy Sandoval,Ingrid E. Wertz,Daniel Christ,Daniel Christ,Christopher C. Goodnow,Christopher C. Goodnow,Shane T. Grey,Shane T. Grey +76 more
TL;DR: Genetic analyses of anatomically modern humans, extinct Denisovan hominins and mice revealed a TNFAIP3 allelic series with alterations in the encoded immune response inhibitor A20, which lower A20 activity and increase autoinflammatory responses.
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IL-21 and IL-4 Collaborate To Shape T-Dependent Antibody Responses.
Helen M. McGuire,Alexis Vogelzang,Joanna Warren,Claudia Loetsch,Karlo D. T. Natividad,Tyani D. Chan,Robert Brink,Marcel Batten,Cecile King +8 more
TL;DR: Analysis of how the fitness of Th cells can influence Ab responses underscores the important collaboration between IL-4 and IL-21 in shaping T-dependent Ab responses.
The retroelement Lx9 puts a brake on the immune response to virus infection
Nenad Bartonicek,Romain Rouet,Joanna Warren,Claudia Loetsch,Gabriela Santos Rodriguez,Stacey N. Walters,Francis Lin,David Zahra,James Blackburn,Jillian M. Hammond,Andre L. M. Reis,Ira W. Deveson,Nathan W. Zammit,Mahdi Zeraati,Shane T. Grey,Daniel Christ,John S. Mattick,Tatyana Chtanova,Robert Brink,Marcel E. Dinger,Robert J. Weatheritt,Jonathan Sprent,Cecile King +22 more
TL;DR: It is shown that CRISPR-Cas9-mediated deletion of a transposable element-namely the LINE-1 retrotransposon Lx9c11-in mice results in an exaggerated and lethal immune response to virus infection.
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Cytokine Expression by T Follicular Helper Cells.
TL;DR: The flow cytometric-based method described here allows the detection of intracellular cytokines within the Tfh population of secondary lymphoid organs (e.g., spleen, lymph nodes, and lymphoid nodules such as Peyer's patches), enabling the study of T fh responses to different stimuli in the context of immunity and autoimmunity.
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