Claro Yu
National Institutes of Health
8 Papers
51 Citations
Claro Yu is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Hepatitis E virus & Virus. The author has an hindex of 8, co-authored 8 publications.
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Papers
Chimpanzees as an animal model for human norovirus infection and vaccine development
Karin Bok,Gabriel I. Parra,Tanaji Mitra,Eugenio J. Abente,Charlene K. Shaver,Denali Boon,Ronald E. Engle,Claro Yu,Albert Z. Kapikian,Stanislav V. Sosnovtsev,Robert H. Purcell,Kim Y. Green +11 more
TL;DR: The chimpanzee is established as a viable animal model for the study of norovirus replication and immunity, and it is shown that NV VLP vaccines could induce protective homologous immunity even after extended periods of time.
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B cell gene signature with massive intrahepatic production of antibodies to hepatitis B core antigen in hepatitis B virus–associated acute liver failure
Patrizia Farci,Giacomo Diaz,Zhaochun Chen,Sugantha Govindarajan,Ashley Tice,Liane Agulto,Stefania Pittaluga,Denali Boon,Claro Yu,Ronald E. Engle,Mark Haas,Richard Simon,Robert H. Purcell,Fausto Zamboni +13 more
TL;DR: It is shown that liver tissue collected at the time of liver transplantation in two patients with HBV-associated ALF is characterized by an overwhelming B cell response apparently centered in the liver with massive accumulation of plasma cells secreting IgG and IgM, accompanied by complement deposition, suggesting that humoral immunity may exert a primary role in the pathogenesis ofHBV- associated ALF.
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Hepatitis E Virus (HEV) Capsid Antigens Derived from Viruses of Human and Swine Origin Are Equally Efficient for Detecting Anti-HEV by Enzyme Immunoassay
TL;DR: The virtually identical results obtained with these antigens in detecting seroconversion following infection with HEV suggests that they were reacting with antibodies that detect the same or very similar epitopes of HEV.
121
Mutations within Potential Glycosylation Sites in the Capsid Protein of Hepatitis E Virus Prevent the Formation of Infectious Virus Particles
Judith Graff,Yi-Hua Zhou,Udana Torian,Hanh T. Nguyen,Marisa St. Claire,Claro Yu,Robert H. Purcell,Suzanne U. Emerson +7 more
TL;DR: Analysis of capsid protein produced during a normal viral replication cycle suggested that the mutations were lethal because they perturbed protein structure rather than because they eliminated glycosylation.
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Detection of Immunoglobulin M Antibodies to Hepatitis E Virus by Class Capture Enzyme Immunoassay
TL;DR: The class capture method was more sensitive than the sandwich EIA when used to test clinical samples from two hepatitis E epidemics in Pakistan; it also had the advantage of distinguishing IgM anti- HEV in the presence of high titers of IgG anti-HEV.
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