Clare Bergson

TL;DR: The anatomical segregation of the D1 and D5 receptors at the subcellular level in cerebral cortex and at the cellular level in subcortical areas suggest that these closely related receptors may be preferentially associated with different circuit elements and may play distinct regulatory roles in synaptic transmission.

TL;DR: D5 receptor antibodies intensely labeled pyramidal neurons in the prefrontal cortex, whereas spiny medium-sized neurons and aspiny large interneurons of the caudate nucleus were relatively lightly labeled.

TL;DR: It is proposed that dopamine receptors of the D1 class play an important role in regulating cerebral cortical formation and that D1 and D5 receptor subtypes may participate in regulation of different aspects of this process.

TL;DR: New findings indicate that a major action of DA in the prefrontal association cortex is to modulate directly excitatory neurotransmission in pyramidal neurons and regulate their ability to integrate their high level sensory input.