Clara Simon
University Hospital of Giessen and Marburg
7 Papers
Clara Simon is an academic researcher from University Hospital of Giessen and Marburg. The author has contributed to research in topics: Biology & Myeloid leukemia. The author has an hindex of 1, co-authored 1 publications.
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Papers
The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain
Lisa Weber,Yu Jia,Bastian Stielow,Stephen S. Gisselbrecht,Yinghua Cao,Yi Ren,Iris Rohner,Jessica King,Elisabeth Rothman,S. Fischer,Clara Simon,Ignasi Forné,Andrea Nist,Thorsten Stiewe,Martha L. Bulyk,Zhanxin Wang,Robert Liefke +16 more
TL;DR: In this paper , the winged helix (WH) domain at the very N-terminus of KAT6A specifically interacts with unmethylated CpG motifs.
The CpG Island-Binding Protein SAMD1 Contributes to an Unfavorable Gene Signature in HepG2 Hepatocellular Carcinoma Cells
Clara Simon,Bastian Stielow,Andrea Nist,Iris Rohner,Lisa Weber,Merle Geller,Sabrina Fischer,Thorsten Stiewe,Robert Liefke +8 more
TL;DR: It is demonstrated that the deletion of SAMD1 in HepG2 cells leads to aberrant gene regulation and to a gene signature linked to a better prognosis, which suggests that S AMD1 is involved in establishing a pro-proliferative setting in hepatocellular carcinoma cells.
IRF2BP2 counteracts the ATF7/JDP2 AP-1 heterodimer to prevent inflammatory overactivation in acute myeloid leukemia (AML) cells
S. Fischer,Lisa Weber,Bastian Stielow,Miriam Frech,Clara Simon,Ignasi Forné,Andrea Nist,Uta-Maria Bauer,Thorsten Stiewe,Andreas Neubauer,Robert Liefke +10 more
TL;DR: In this paper , the authors demonstrate that IRF2BP2 interacts with the AP-1 heterodimer ATF7/JDP2, which is involved in activating inflammatory pathways in AML cells.
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Cloning and characterization of a novel druggable fusion kinase in acute myeloid leukemia
Christian Michel,Elisabeth Mack,Christopher-Nils Mais,Lea V. Fritz,Ying Wang,Lutz B. Jehn,Sonja K. Hühn,Clara Simon,Sabrina Inselmann,André Marquardt,Jennifer Kremer,Ellen Wollmer,Kristina Sohlbach,Andreas Neubauer,Cornelia Brendel,Claudia Haferlach,Gert Bange,Andreas Burchert +17 more
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SAMD1 suppresses epithelial-mesenchymal transition (EMT) pathways in pancreatic ductal adenocarcinoma
Clara Simon,Inka D. Brunke,Bastian Stielow,Ignasi Forné,A. Steitz,Merle Geller,Iris Rohner,Lisa Weber,S. Fischer,Lea Marie Jeude,Andrea Nist,Thorsten Stiewe,Magdalena Huber,Malte Buchholz,Robert Liefke +14 more
TL;DR: New insights are provided into the regulation of EMT-related genes in PDAC, shedding light on the intricate role of SAMD1 and its interplay with FBXO11 in this cancer type.