Claire N. Bedbrook
California Institute of Technology
19 Papers
65 Citations
Claire N. Bedbrook is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Biology & Channelrhodopsin. The author has an hindex of 12, co-authored 14 publications.
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Papers
The jellyfish Cassiopea exhibits a sleep-like state
Ravi D. Nath,Ravi D. Nath,Claire N. Bedbrook,Michael Abrams,Ty Basinger,Justin S. Bois,David A. Prober,Paul W. Sternberg,Paul W. Sternberg,Viviana Gradinaru,Lea Goentoro +10 more
TL;DR: Results indicate that Cassiopea has a sleep-like state, supporting the hypothesis that sleep arose early in the metazoan lineage, prior to the emergence of a centralized nervous system.
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Machine learning-guided channelrhodopsin engineering enables minimally invasive optogenetics
Claire N. Bedbrook,Kevin K. Yang,J. Elliott Robinson,Elisha D.W. Mackey,Viviana Gradinaru,Frances H. Arnold +5 more
TL;DR: An engineering approach guided by machine learning results in high-performance channelrhodopsin variants that are suitable for systemic viral delivery and illumination through a thinned skull.
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Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons
Nicholas C. Flytzanis,Claire N. Bedbrook,Hui Chiu,Martin K. M. Engqvist,Cheng Xiao,Ken Y. Chan,Paul W. Sternberg,Frances H. Arnold,Viviana Gradinaru +8 more
TL;DR: Fluorescence voltage sensing in behaving C. elegans is shown as a proof-of-concept for the application of Arch-based sensors in vivo, and Archer1 is capable of wavelength specific functionality as a voltage sensor under red-light and as an inhibitory actuator under green-light.
Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins in vivo
Claire N. Bedbrook,Mihoko Kato,Sripriya Ravindra Kumar,Anupama Lakshmanan,Ravi D. Nath,Fei Sun,Paul W. Sternberg,Frances H. Arnold,Viviana Gradinaru +8 more
TL;DR: It is shown that the genetically encoded, covalent binding SpyTag and SpyCatcher pair from the Streptococcus pyogenes fibronectin-binding protein FbaB can selectively label membrane-localized proteins in living cells in culture and in vivo in Caenorhabditis elegans.
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Machine learning-guided channelrhodopsin engineering enables minimally-invasive optogenetics
TL;DR: These engineered light-gated channelrhodopsins enable light-induced neuronal excitation without invasive intracranial surgery for virus delivery or fiber optic implantation, i.e. they enable minimally-invasive optogenetics.
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