Claire M. Fraser
University of Maryland, Baltimore
364 Papers
5.1K Citations
Claire M. Fraser is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 108, co-authored 352 publications. Previous affiliations of Claire M. Fraser include Novartis & Manchester Academic Health Science Centre.
Chat about Author
Papers
Molecular mechanisms of probiotic prevention of antibiotic-associated diarrhea.
TL;DR: What is currently known about how probiotics reduce the risk for antibiotic-associated diarrhea via modulating the gut microbiota, altering nutrient and bile acid metabolism, inducing epithelial solute transporter activity, supporting intestinal barrier function, and influencing the immune system is examined.
141
Continuous monitoring of receptor-mediated changes in the metabolic rates of living cells.
John C. Owicki,J. W. Parce,K. M. Kercso,G B Sigal,V.C. Muir,J C Venter,Claire M. Fraser,Harden M. McConnell +7 more
TL;DR: Monitoring cell metabolism with a silicon-based microphysiometer illustrates an alternative means of studying cellular responses to hormones and neurotransmitters and suggests that metabolic changes will be generally useful for detecting the consequences of receptor-ligand interactions.
140
Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes
Simon P. Graham,Roger Pelle,Yoshikazu Honda,Duncan Mwangi,Nyerhovwo J. Tonukari,Mat Yamage,E. Jane Glew,Etienne P. de Villiers,Trushar Shah,Richard P. Bishop,Evelyne Abuya,Elias Awino,James Gachanja,Anthony E. Luyai,Ferdinand Mbwika,Anthony M. Muthiani,David Ndegwa,Moses N. Njahira,John K. Nyanjui,Fredrick O. Onono,Julius Osaso,Rosemary Saya,Claude Wildmann,Claire M. Fraser,Ian Maudlin,Malcolm J. Gardner,Subhash Morzaria,Sheena M. Loosmore,Sarah C. Gilbert,J.C. Audonnet,Pierre van der Bruggen,Vishvanath Nene,Evans L. N. Taracha +32 more
TL;DR: The identification of five candidate vaccine antigens that are the targets of MHC class I-restricted CD8(+) CTL from immune cattle provide a basis for developing a CTL-targeted anti-East Coast fever subunit vaccine and orthologs of these antigen may be vaccine targets for other apicomplexan parasites.
138
Genetic exchange and plasmid transfers in Borrelia burgdorferi sensu stricto revealed by three-way genome comparisons and multilocus sequence typing
Wei-Gang Qiu,Steven E. Schutzer,John F. Bruno,Oliver Attie,Yun Xu,John J. Dunn,Claire M. Fraser,Sherwood R. Casjens,Benjamin J. Luft +8 more
TL;DR: It is concluded that B. burgdorferi undergoes genome-wide genetic exchange, including plasmid transfers, and previous reports of its clonality are artifacts from the use of geographically and ecological isolated samples.
137
Strain-Specific Single-Nucleotide Polymorphism Assays for the Bacillus anthracis Ames Strain
Matthew N. Van Ert,W. Ryan Easterday,Tatum S. Simonson,Jana M. U'Ren,Talima Pearson,Leo J. Kenefic,Joseph D. Busch,Lynn Y. Huynh,Megan Dukerich,Carla B. Trim,Jodi A. Beaudry,Amy Welty-Bernard,Timothy D. Read,Claire M. Fraser,Jacques Ravel,Paul Keim,Paul Keim +16 more
TL;DR: Six SNPs were found to be highly specific for the Ames strain, the strain used in the 2001 bioterrorist attacks in the United States, and this evolutionary and genomics-based approach provides an effective means for the discovery of strain-specific SNPs in B. anthracis.
137