Clair Gallagher
Dublin City University
22 Papers
59 Citations
Clair Gallagher is an academic researcher from Dublin City University. The author has contributed to research in topics: Chinese hamster ovary cell & Cell growth. The author has an hindex of 12, co-authored 22 publications.
Chat about Author
Papers
CHO cell culture longevity and recombinant protein yield are enhanced by depletion of miR-7 activity via sponge decoy vectors.
Noelia Sanchez,Paul S. Kelly,Clair Gallagher,Nga T. Lao,Colin Clarke,Martin Clynes,Niall Barron +6 more
TL;DR: It is demonstrated that miRNA sponge transcripts could potentially be used in cell line development projects to generate producer clones that grow to higher densities and last longer in the bioreactor - thereby improving product yield.
54
Demodex-associated Bacillus proteins induce an aberrant wound healing response in a corneal epithelial cell line: possible implications for corneal ulcer formation in ocular rosacea.
Niamh O'Reilly,Clair Gallagher,Kishore Reddy Katikireddy,Martin Clynes,Finbarr O'Sullivan,Kevin Kavanagh +5 more
TL;DR: The results indicate that exposure of corneal epithelial cells to Bacillus proteins results in an aberrant wound healing response and suggest a possible link between the high density of Demodex mites on the eyelashes of ocular rosacea patients and the development of Corneal ulcers.
Loss of photoreceptor potential from retinal progenitor cell cultures, despite improvements in survival.
Fiona C. Mansergh,Reaz Vawda,Sophia Millington-Ward,Paul F. Kenna,Jochen Haas,Clair Gallagher,John H. Wilson,Peter Humphries,Marius Ader,Marius Ader,G. Jane Farrar +10 more
TL;DR: Improvement of cell culture protocols for retinal progenitor cells (RPCs) derived from PN3-5 retinal cells in vitro succeeded in improving RPC survival and growth rates 25-fold, by modifying retinal dissociation.
30
Prolonged pre-incubation increases the susceptibility of Galleria mellonella larvae to bacterial and fungal infection
Niall Browne,Carla Surlis,Amie Maher,Clair Gallagher,James C. Carolan,Martin Clynes,Kevin Kavanagh +6 more
TL;DR: The aim of the work described here was to ascertain the effect of pre-incubation at 15°C for 1, 3, 6 or 10 weeks on the susceptibility of larvae to infection with Candida albicans and Staphylococcus aureus.
27
Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL
Alex J Eustace,Neil T Conlon,Martina McDermott,Brigid C. Browne,Patrick O’Leary,Frankie A. Holmes,Virginia Espina,Lance A. Liotta,Joyce O'Shaughnessy,Clair Gallagher,Lorraine O'Driscoll,Sweta Rani,Stephen F. Madden,Stephen F. Madden,Neil A. O'Brien,Charles Ginther,Dennis J. Slamon,Naomi Walsh,William M. Gallagher,Radoslaw Zagozdzon,William Watson,Norma O'Donovan,John Crown +22 more
TL;DR: The findings highlight the possibility of targeting altered apoptotic signalling to overcome acquired lapatinib resistance, and identify potential novel treatment strategies, with potential biomarkers, for HER2-positive breast cancer that is resistant to HER2 targeted therapies.