Ciprian B. Anea
Georgia Regents University
13 Papers
9 Citations
Ciprian B. Anea is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Circadian clock & Circadian rhythm. The author has an hindex of 8, co-authored 13 publications.
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Papers
Vascular disease in mice with a dysfunctional circadian clock.
Ciprian B. Anea,Maoxiang Zhang,David W. Stepp,G. Bryan Simkins,Guy L. Reed,David J. Fulton,R. Daniel Rudic +6 more
TL;DR: Increased pathological remodeling and vascular injury in mice with aberrant circadian rhythms, Bmal1-knockout and Clock mutant mice are found and reveal a new role for the circadian clock during chronic vascular responses that may be of significance in the progression of vascular disease.
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Increased Superoxide and Endothelial NO Synthase Uncoupling in Blood Vessels of Bmal1-Knockout Mice
Ciprian B. Anea,Bo Cheng,Bo Cheng,Shruti Sharma,Sanjiv Kumar,R. William Caldwell,Lin Yao,M. Irfan Ali,Ana M. Merloiu,David W. Stepp,Stephen M. Black,David Fulton,R. Daniel Rudic +12 more
TL;DR: In this article, the impact of the circadian clock on endothelial NO synthase coupling and reactive oxygen species levels in arteries from Bmal1-knockout (KO) mice was investigated.
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Tissue-intrinsic dysfunction of circadian clock confers transplant arteriosclerosis
Bo Cheng,Ciprian B. Anea,Lin Yao,Feng Chen,Vijay Patel,Ana M. Merloiu,Paramita Pati,R. William Caldwell,David J. Fulton,R. Daniel Rudic +9 more
TL;DR: The significance of intrinsic tissue clocks as an autonomous influence in experimental models of arteriosclerotic disease is demonstrated, which may have implications with regard to the influence of circadian clock function in organ transplantation.
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Matrix Metalloproteinase 2 and 9 Dysfunction Underlie Vascular Stiffness in Circadian Clock Mutant Mice
Ciprian B. Anea,M. Irfan Ali,Jessica M. Osmond,Jennifer C. Sullivan,David W. Stepp,Ana M. Merloiu,R. Daniel Rudic +6 more
TL;DR: High-resolution ultrasonography in vivo revealed impaired remodeling and increased pulse-wave velocity in the arteries of Bmal1-KO and Per-triple KO mice, which may involve impaired control of the extracellular matrix composition.
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Circadian clock control of Nox4 and reactive oxygen species in the vasculature
Ciprian B. Anea,Maoxiang Zhang,Feng Chen,M. Irfan Ali,C. Michael Hart,David W. Stepp,Yevgeniy Kovalenkov,Ana M. Merloiu,Paramita Pati,David Fulton,R. Daniel Rudic +10 more
TL;DR: Data reveal that the circadian clock plays an important role in the control of Nox4 and disruption of the clock leads to subsequent production of reaction oxygen species.