Ciaran P. Kelly
Beth Israel Deaconess Medical Center
360 Papers
1.8K Citations
Ciaran P. Kelly is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Clostridium difficile & Medicine. The author has an hindex of 81, co-authored 334 publications. Previous affiliations of Ciaran P. Kelly include Trinity College, Dublin & Boston University.
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Papers
Development and Validation of Digital Enzyme-Linked Immunosorbent Assays for Ultrasensitive Detection and Quantification of Clostridium difficile Toxins in Stool
Linan Song,Mingwei Zhao,David C. Duffy,Joshua Hansen,Kelsey Shields,Manida Wungjiranirun,Xinhua Chen,Hua Xu,Daniel A. Leffler,Susan P. Sambol,Dale N. Gerding,Ciaran P. Kelly,Nira R. Pollock,Nira R. Pollock +13 more
TL;DR: Ultrasensitive digital ELISAs for the detection and quantification of toxins A and B in stool can provide a rapid and simple tool for the diagnosis of CDI with both high analytical sensitivity and high clinical specificity.
Safety and efficacy of E. coli enterotoxin adjuvant for urease-based rectal immunization against Helicobacter pylori
Stavros Sougioultzis,Cynthia K. Lee,Mazen Alsahli,Subhas Banerjee,Michel Cadoz,Robert Schrader,Bruno Guy,Philip Bedford,Thomas P. Monath,Ciaran P. Kelly,Pierre Michetti +10 more
TL;DR: In this paper, the safety and adjuvant efficacy of rectally delivered heat-labile enterotoxin (LT) together with recombinant H. pylori urease was evaluated.
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Probiotics for Celiac Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Caroline L Seiler,Michel Kiflen,Juan Pablo Stefanolo,Julio C. Bai,Premysl Bercik,Ciaran P. Kelly,Elena F. Verdu,Paul Moayyedi,Maria Ines Pinto-Sanchez +8 more
TL;DR: A systematic review and meta-analysis to evaluate the efficacy of probiotics in improving gastrointestinal symptoms and quality of life (QOL) in patients with celiac disease found that the overall certainty of the evidence ranged from very low to low.
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Salivary Gluten Degradation and Oral Microbial Profiles in Healthy Individuals and Celiac Disease Patients
Na Tian,Lina L. Faller,Daniel A. Leffler,Ciaran P. Kelly,Joshua Hansen,Jos A. Bosch,Guoxian Wei,Bruce J. Paster,Bruce J. Paster,Detlef Schuppan,Eva J. Helmerhorst +10 more
TL;DR: Investigating salivary enzymatic activities and oral microbial profiles in healthy subjects versus patients with classical and refractory CD suggested that oral microbe-derived enzyme activities are elevated in subjects with CD, which may impact gluten processing and the presentation of immunogenic gluten epitopes to the immune system in the small intestine.
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Prevention of recurrent Clostridioides difficile infection: A systematic review of randomized controlled trials.
TL;DR: Several CDI-specific antibiotics, FMT modalities, monoclonal antibodies, and various prebiotics and probiotics demonstrated a reduction in risk of rCDI with the greatest risk reduction observed with FMT and monoconal antibody therapy.
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