Chunsun Dai
Nanjing Medical University
50 Papers
125 Citations
Chunsun Dai is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Kidney & Fibrosis. The author has an hindex of 24, co-authored 50 publications.
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Papers
Wnt/ β -Catenin-Promoted Macrophage Alternative Activation Contributes to Kidney Fibrosis.
Ye Feng,Jiafa Ren,Yuan Gui,Wei Wei,Bingyan Shu,Qingmiao Lu,Xian Xue,Xiaoli Sun,Weichun He,Junwei Yang,Chunsun Dai +10 more
TL;DR: It is shown that activation of Wnt/β-catenin signaling promotes kidney fibrosis by stimulating macrophage M2 polarization and preventing IL-4- or TGFβ1-induced Macrophage alternative (M2) polarization processes.
219
WNT/β-catenin signaling promotes VSMCs to osteogenic transdifferentiation and calcification through directly modulating Runx2 gene expression.
TL;DR: It is suggested that high-phosphate may activate WNT/β-catenin signaling through different pathways, and the activated WNT-3A/ β-catanin signaling, through direct downstream target Runx2, could play an important role in promoting VOT and AMC.
203
Uric Acid Induces Renal Inflammation via Activating Tubular NF-κB Signaling Pathway
TL;DR: It is suggested that uric acid induces renal inflammation via activation of NF-κB signaling through infiltration of T cells and macrophages in hyperuricemia mice kidneys.
Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction
Jianzhong Li,Yuan Gui,Jiafa Ren,Xin Liu,Ye Feng,Zhifeng Zeng,Weichun He,Junwei Yang,Chunsun Dai +8 more
TL;DR: It is demonstrated that metformin may protect against cisplatin-induced tubular cell apoptosis and AKI through stimulating AMPKα activation and autophagy induction in the tubular cells.
Role of pyruvate kinase M2-mediated metabolic reprogramming during podocyte differentiation.
Qi Yuan,Jiao Miao,Qianqian Yang,Li Fang,Yi Fang,Hao Ding,Yang Zhou,Lei Jiang,Chunsun Dai,Ke Zen,Qi Sun,Junwei Yang +11 more
TL;DR: Mammalian target of rapamycin (mTOR) is identified as a critical regulator of PKM2 during podocyte development, and a stronger glycolytic profile is observed, accompanied by an increased mitochondrial complexity in differentiated podocytes, indicating that mature podocytes boost both gly colysis and mitochondrial metabolism to meet their augmented energy demands.