Chunhua Dai
Vanderbilt University Medical Center
68 Papers
759 Citations
Chunhua Dai is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Islet & Biology. The author has an hindex of 35, co-authored 58 publications. Previous affiliations of Chunhua Dai include United States Department of Veterans Affairs & Vanderbilt University.
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Papers
α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes
Marcela Brissova,Rachana Haliyur,Diane C. Saunders,Shristi Shrestha,Chunhua Dai,David M. Blodgett,David M. Blodgett,Rita Bottino,Martha Campbell-Thompson,Radhika Aramandla,Gregory Poffenberger,Jill Lindner,Fong Cheng Pan,Matthias von Herrath,Dale L. Greiner,Leonard D. Shultz,May Sanyoura,Louis H. Philipson,Mark A. Atkinson,David M. Harlan,Shawn Levy,Nripesh Prasad,Roland Stein,Roland Stein,Alvin C. Powers,Alvin C. Powers,Alvin C. Powers +26 more
TL;DR: It is shown that remnant β cells appeared to maintain several aspects of regulated insulin secretion, however, the function of T1D α cells was markedly reduced, and these cells had alterations in transcription factors constituting α and β cell identity.
188
Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation
E. Danielle Dean,Mingyu Li,Mingyu Li,Nripesh Prasad,Scott Wisniewski,Alison Von Deylen,Jason M. Spaeth,Lisette A. Maddison,Anthony Botros,Leslie R Sedgeman,Nadejda Bozadjieva,Olga Ilkayeva,Anastasia Coldren,Greg Poffenberger,Alena Shostak,Michael C Semich,Kristie Aamodt,Neil Phillips,Hai Yan,Ernesto Bernal-Mizrachi,Jackie D Corbin,Kasey C. Vickers,Shawn Levy,Chunhua Dai,Christopher B. Newgard,Wei Gu,Roland Stein,Wenbiao Chen,Alvin C. Powers +28 more
TL;DR: A hepatic α islet cell axis where glucagon regulates serum AA availability and AAs, especially L-glutamine, regulate α cell proliferation and mass via mTOR-dependent nutrient sensing is indicated.
181
SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells
Katie C. Coate,Jeeyeon Cha,Shristi Shrestha,Wenliang Wang,Luciana Mateus Gonçalves,Joana Almaça,Meghan E. Kapp,Maria Fasolino,Ashleigh Morgan,Chunhua Dai,Diane C. Saunders,Rita Bottino,Radhika Aramandla,Regina Jenkins,Roland Stein,Klaus H. Kaestner,Golnaz Vahedi,Marcela Brissova,Alvin C. Powers,Alvin C. Powers +19 more
TL;DR: Findings reduce the likelihood that SARS-CoV-2 directly infects β cells in vivo through ACE2 and TMPRSS2 through co-expression of its canonical cell entry factors, angiotensin converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPR SS2).
178
Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets
Chunhua Dai,Marcela Brissova,Y. Hang,Courtney S. Thompson,Greg Poffenberger,Alena Shostak,Zhongyi Chen,Roland Stein,Alvin C. Powers,Alvin C. Powers +9 more
TL;DR: The results suggest that human islets have a distinctive distribution and function of key regulators of the glucose-stimulated insulin secretion pathway, emphasising the urgent need to understand the processes that regulate human islet beta cell function.
Cystic fibrosis–related diabetes is caused by islet loss and inflammation
Nathaniel J. Hart,Radhika Aramandla,Gregory Poffenberger,Cody Fayolle,Ariel H. Thames,Austin Bautista,Aliya F. Spigelman,Jenny Aurielle B. Babon,Megan E DeNicola,Prasanna K. Dadi,William S. Bush,Appakalai N. Balamurugan,Marcela Brissova,Chunhua Dai,Nripesh Prasad,Rita Bottino,David A. Jacobson,Mitchell L. Drumm,Sally C. Kent,Patrick E. MacDonald,Alvin C. Powers,Alvin C. Powers +21 more
TL;DR: Results indicate that CFRD is caused by β cell loss and intraislet inflammation in the setting of a complex pleiotropic disease and not by intrinsic islet dysfunction from CFTR mutation.