Chun Yang
Medical College of Wisconsin
57 Papers
126 Citations
Chun Yang is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 15, co-authored 37 publications. Previous affiliations of Chun Yang include Sir Run Run Shaw Hospital & University of Wisconsin–Milwaukee.
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Papers
Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats.
Allen W. Cowley,Chun Yang,Nadezhda N. Zheleznova,Alexander Staruschenko,Theresa Kurth,Lisa Rein,Vikash Kumar,Katherine Sadovnikov,Alex Dayton,Matthew Hoffman,Robert P. Ryan,Meredith M. Skelton,Fahimeh Salehpour,Mahsa Ranji,Aron M. Geurts +14 more
TL;DR: It is concluded that the reduced renal injury and attenuated blood pressure response to high salt in the SSNox4−/− rat could be the result of multiple pathways, including gene transcription, mitochondrial energetics, oxidative stress, and protein matrix production impacted by the knock out of Nox4.
90
Mitochondrial proteomic analysis reveals deficiencies in oxygen utilization in medullary thick ascending limb of Henle in the Dahl salt-sensitive rat.
Nadezhda N. Zheleznova,Chun Yang,Robert P. Ryan,Brian D. Halligan,Mingyu Liang,Andrew S. Greene,Allen W. Cowley +6 more
TL;DR: Oxygen consumption and high-resolution respirometry analyses showed that mTAL cells and the mitochondria in the outer medulla of SS rats fed high-salt diet exhibited lower rates of oxygen utilization compared with those from SS.13(BN) rats.
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Dynamic convergence and divergence of renal genomic and biological pathways in protection from Dahl salt-sensitive hypertension.
Limin Lu,Peigang Li,Chun Yang,Terry Kurth,Michael Misale,Meredith M. Skelton,Carol Moreno,Richard J. Roman,Andrew S. Greene,Howard J. Jacob,Jozef Lazar,Mingyu Liang,Allen W. Cowley +12 more
TL;DR: The findings suggest that different genetic alterations might converge to influence shared pathways in protection from hypertension, and that, depending on the genomic context, the same genetic alteration might diverge to affect different pathways.
35
Role of Nox4 and p67phox subunit of Nox2 in ROS production in response to increased tubular flow in the mTAL of Dahl salt-sensitive rats.
TL;DR: It is concluded that increased mTAL luminal flow results in increases in intracellular and mitochondrial H2O2, which are dependent on the presence of Nox4, and that p67phox/Nox2 accounts solely for increases in O2 (·-) production.
31
Increased Proliferative Cells in the Medullary Thick Ascending Limb of the Loop of Henle in the Dahl Salt-Sensitive Rat
Chun Yang,Francesco C. Stingo,Kwang Woo Ahn,Pengyuan Liu,Marina Vannucci,Purushottam W. Laud,Meredith M. Skelton,Paul M. O'Connor,Terry Kurth,Robert P. Ryan,Carol Moreno,Shirng Wern Tsaih,Giannino Patone,Oliver Hummel,Howard J. Jacob,Mingyu Liang,Allen W. Cowley +16 more
TL;DR: The study revealed alterations in regulatory pathways in Dahl salt-sensitive rats in tissues highly enriched for a single cell type, leading to the unexpected finding of a greater increase in the number of proliferative medullary thick ascending limb cells in Dahl Salt- sensitive rats on a high-salt diet.
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