Chun Wang
Central South University
5 Papers
Chun Wang is an academic researcher from Central South University. The author has contributed to research in topics: Fatty acid synthesis & Reductase. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Chun Wang include University of South China & Southern Illinois University School of Medicine.
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Papers
Aldo-keto Reductase Family 1 Member B10 Promotes Cell Survival by Regulating Lipid Synthesis and Eliminating Carbonyls *
TL;DR: It is demonstrated that AKR1B10 is critical to cell survival through modulating lipid synthesis, mitochondrial function, and oxidative status, as well as carbonyl levels, being an important cell survival protein.
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Acetyl-CoA carboxylase-a as a novel target for cancer therapy.
TL;DR: Recent findings suggest that ACCA might be effective as a potent target for cancer intervention, and the inhibitors developed for the treatment of metabolic diseases would be potential therapeutic agents for cancer therapy.
87
Murine aldo-keto reductase family 1 subfamily B: identification of AKR1B8 as an ortholog of human AKR1B10.
TL;DR: It is suggested that murine AKR1B8 is the ortholog of human AKR 1B10, which associates with murine acetyl-CoA carboxylase-α and mediates fatty acid synthesis in colon cancer cells.
27
Targeting Acetyl-CoA Carboxylases: Small Molecular Inhibitors and their Therapeutic Potential
TL;DR: This article provides a comprehensive review and updates of ACC inhibitors, with a focus on their therapeutic application in metabolic syndromes and malignant diseases.
Acetyl-CoA Carboxylase-α Inhibitor TOFA Induces Human Cancer Cell Apoptosis
TL;DR: It is suggested that TOFA (5-tetradecyloxy-2-furoic acid), an allosteric inhibitor of ACCA, is a potent cytotoxic agent to lung and colon cancer cells, inducing apoptosis through disturbing their fatty acid synthesis.