Chun Chen
Amgen
27 Papers
85 Citations
Chun Chen is an academic researcher from Amgen. The author has contributed to research in topics: Breast cancer & Cancer cell. The author has an hindex of 14, co-authored 27 publications. Previous affiliations of Chun Chen include Nanjing University & Virginia Tech.
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Papers
Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization
Geming Lu,Ruihua Zhang,Shuo Geng,Liang Peng,Padmini Jayaraman,Chun Chen,Feifong Xu,Jianjun Yang,Qin Li,Hao Zheng,Kimberly Shen,Juan Wang,Xiyu Liu,Weidong Wang,Zihan Zheng,Chen Feng Qi,Chuanping Si,John Cijiang He,Kebin Liu,Sergio A. Lira,Andrew G. Sikora,Liwu Li,Huabao Xiong +22 more
TL;DR: In this article, iNOS-deficient mice display enhanced classically activated M1 macrophage polarization without major effects on alternatively activated M2 macrophages, while adding N6-(1-iminoethyl)-L-lysine dihydrochloride and S-nitroso-N-acetylpenicillamine, a NO donor, suppresses M1 macroscopic polarization.
The persistence of low-grade inflammatory monocytes contributes to aggravated Atherosclerosis
Shuo Geng,Keqiang Chen,Ruoxi Yuan,Liang Peng,Urmila Maitra,Na Diao,Chun Chen,Yao Zhang,Yuan Hu,Chen-Feng Qi,Susan K. Pierce,Wenhua Ling,Huabao Xiong,Liwu Li +13 more
TL;DR: Subclinical endotoxemia, often seen in humans with chronic inflammation, aggravates murine atherosclerosis through programming monocytes into a non-resolving inflammatory state with elevated Ly6C, CCR5, MCP-1 and reduced SR-B1.
Two independent positive feedbacks and bistability in the Bcl-2 apoptotic switch.
TL;DR: The studies successfully elucidate the switch mechanism embedded in the Bcl-2 interaction network and provide insights into pharmacological manipulation of B cl-2 apoptotic switch as further cancer therapies.
Reprogramming macrophage orientation by microRNA 146b targeting transcription factor IRF5
Liang Peng,Hui Zhang,Yuanyuan Hao,Feihong Xu,Jianjun Yang,Ruihua Zhang,Geming Lu,Zihan Zheng,Miao Cui,Chen-Feng Qi,Chun Chen,Juan Wang,Yuan Hu,Di Wang,Susan K. Pierce,Liwu Li,Huabao Xiong +16 more
TL;DR: It is shown that IL-10 and Rag1 double knockout mice spontaneously develop colitis with dominant M1 macrophage phenotype, suggesting thatIL-10 regulates macrophages orientation in inflammation and that miR-146b targets IRF5, resulting in the regulation ofmacrophage activation.
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Robustness analysis identifies the plausible model of the Bcl-2 apoptotic switch.
TL;DR: By investigating the robustness of other important features of the Bcl‐2 apoptotic switch (including low Bax basal activation, inhibitory role of anti‐apoptotic proteins and insensitivity to small perturbations) the direct activation model was further supported.
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