Chuming Luo
University of Minnesota
9 Papers
22 Citations
Chuming Luo is an academic researcher from University of Minnesota. The author has contributed to research in topics: Coronavirus & Pathogenesis. The author has an hindex of 6, co-authored 6 publications.
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Papers
Structural basis of receptor recognition by SARS-CoV-2.
Jian Shang,Gang Ye,Ke Shi,Yushun Wan,Chuming Luo,Hideki Aihara,Qibin Geng,Ashley Auerbach,Fang Li +8 more
TL;DR: This study determines the crystal structure of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 (engineered to facilitate crystallization) in complex with ACE2 and sheds light on the structural features that increase its binding affinity to ACE2.
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Cell entry mechanisms of SARS-CoV-2.
TL;DR: Key cell entry mechanisms of SARS-CoV-2 that potentially contribute to the immune evasion, cell infectivity, and wide spread of the virus are identified using biochemical and pseudovirus entry assays and the potency and evasiveness are highlighted.
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Cryo-EM structure of infectious bronchitis coronavirus spike protein reveals structural and functional evolution of coronavirus spike proteins
TL;DR: The cryo-EM structure of avian infectious bronchitis coronavirus (IBV) spike protein from the γ-genus is determined and it is proposed that the evolutionary spectrum of coronav virus spikes follows the order of α-, δ-, γ-, and β-genu.
Elevated Human Dipeptidyl Peptidase 4 Expression Reduces the Susceptibility of hDPP4 Transgenic Mice to Middle East Respiratory Syndrome Coronavirus Infection and Disease.
Abdullah Algaissi,Abdullah Algaissi,Anurodh S. Agrawal,Song Han,Bi Hung Peng,Chuming Luo,Fang Li,Teh Sheng Chan,Robert B. Couch,Chien Te K. Tseng +9 more
TL;DR: It is suggested that the serum shDPP4 levels play a role in MERS pathogenesis and a potential of rshDPP 4 as a treatment option for MERS is demonstrated.
The truncated IFITM3 facilitates the humoral immune response in inactivated influenza vaccine-vaccinated mice via interaction with CD81
Qian Xie,Xinzhong Liao,Bi Huang,Liangliang Wang,Guancheng Liao,Chuming Luo,Simin Wen,Shisong Fang,Huanle Luo,Yuelong Shu +9 more
TL;DR: A mouse model with a deletion of 21 amino acids at the N-terminus of IFITM3 revealed a potential mechanism of NΔ21 protein enhancing humoral immune response by relocation to prevent the degradation of CD81, providing insight into SNP affecting influenza vaccination.
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