Molecularly-imprinted polymer sensors: realising their potential.

Herein, we present a survey of the literature covering the development of molecular imprinting science and technology over the years 2004-2011. In total, 3779 references to the original papers, rev ...

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011.

Label-free optical biosensors are an intriguing option for the analyses of many analytes, as they offer several advantages such as high sensitivity, direct and real-time measurement in addition to multiplexing capabilities. However, development of label-free optical biosensors for small molecules can be challenging as most of them are not naturally chromogenic or fluorescent, and in some cases, the sensor response is related to the size of the analyte. To overcome some of the limitations associated with the analysis of biologically, pharmacologically, or environmentally relevant compounds of low molecular weight, recent advances in the field have improved the detection of these analytes using outstanding methodology, instrumentation, recognition elements, or immobilization strategies. In this review, we aim to introduce some of the latest developments in the field of label-free optical biosensors with the focus on applications with novel innovations to overcome the challenges related to small molecule detection. Optical label-free methods with different transduction schemes, including evanescent wave and optical fiber sensors, surface plasmon resonance, surface-enhanced Raman spectroscopy, and interferometry, using various biorecognition elements, such as antibodies, aptamers, enzymes, and bioinspired molecularly imprinted polymers, are reviewed.

Optical Biosensors for Label-Free Detection of Small Molecules

Molecularly imprinted polymers for the determination of organophosphorus pesticides in complex samples

A novel colorimetric sensor for cholesterol assay was constructed by combining a molecular imprinting technique with photonic crystals. The molecularly imprinted photonic hydrogel (MIPH) film was prepared by a non-covalent, self-assembly approach using cholesterol as a template molecule, and exhibited a highly ordered three-dimensional macroporous structure characterized by scanning electron microscopy under the optimized imprinting conditions. Various factors affecting rebinding of cholesterol are discussed along with recognition specificity studies on its analogues of stigmasterol and ergosterol through estimation of UV-Vis and electrochemical impedance spectroscopy. The MIPH film generated a significantly readable optical signal directly self-reporting within less than 2 min upon binding cholesterol. The colorimetric measurement of cholesterol concentration strongly relies on the fact that the blue shift effect of the Bragg diffraction peak of the MIPH is gradually enlarged with the increase of cholesterol amounts. The detection level approached 10−13 g mL−1, which is comparable to that of fluorescence measurements. The simultaneous possession of high selectivity, high sensitivity, high stability, easy operation and being label-free enables this sensor to be potentially applicable for rapid on-site detection of trace cholesterol.

/pdf/label-free-colorimetric-detection-of-trace-cholesterol-based-m03od00qcl.pdf

Label-free colorimetric detection of trace cholesterol based on molecularly imprinted photonic hydrogels

Ultrasensitively sensing acephate using molecular imprinting techniques on a surface plasmon resonance sensor.

A surface plasmon resonance (SPR)-based detection methodology, which allows the identification and quantification of the plant hormone, 1H-indole-3-acetic acid (IAA) in Peach, Rosa flower, and Crape myrtle bud is described. To achieve high selectivity, a molecularly imprinted monolayer (MIM) was prepared from alkanethiols self-assembled on an SPR sensor chip with preadsorbed template (IAA). The association constant of the MIM to IAA was calculated to be 2.8 × 1011 M−1 by analysis of the SPR wavenumber changes induced by different concentrations of IAA. A good calibration curve was obtained in a low concentration range of IAA. Moreover, the MIM revealed impressive selectivity with the selectivity factors of 1.0, 0.12, and 0.20 for IAA and other related analogues. Compared to the MIM sensor chip, the affinity of the self-assembled monolayer (SAM) control sensor chip for IAA was significantly low. The single SPR sensor decorated with the MIM was used to determine IAA concentrations in peach, Rosa flower, and...

On-Line Monitoring 1H-Indole-3-Acetic Acid in Plant Tissues Using Molecular Imprinting Monolayer Techniques on a Surface Plasmon Resonance Sensor

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Ultrasensitively sensing acephate using molecular imprinting techniques on a surface plasmon resonance sensor.

On-Line Monitoring 1H-Indole-3-Acetic Acid in Plant Tissues Using Molecular Imprinting Monolayer Techniques on a Surface Plasmon Resonance Sensor