Chuan He Yang
University of Tennessee Health Science Center
45 Papers
394 Citations
Chuan He Yang is an academic researcher from University of Tennessee Health Science Center. The author has contributed to research in topics: Interferon & Signal transduction. The author has an hindex of 25, co-authored 43 publications.
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Papers
The Role of miR-21 in Cancer.
TL;DR: In this paper, the role of miR-21 and its target genes in different cancers, and provide insight into how this oncogenic miRNA regulates cancer cell proliferation, migration, and apoptosis by suppressing the expression of tumor suppressors.
309
STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor.
TL;DR: STAT3, a transcription factor for acute phase response genes, was found to act as an adapter molecule in signal transduction from the type I interferon receptor.
278
Interferon α/β Promotes Cell Survival by Activating Nuclear Factor κB through Phosphatidylinositol 3-Kinase and Akt
TL;DR: STAT3, PI-3K, and Akt are components of an IFN signaling pathway that promotes cell survival through NF-κB activation, and Ly294002, a dominant-negative PI- 3K construct, and kinase-dead Akt block IFN-promoted cell survival, enhancing apoptotic cell death.
197
•Journal Article
Induction of Jak/STAT Signaling by Activation of the Type 1 TNF Receptor
TL;DR: It is demonstrated that the cytoplasmic domain of TNFR1 can directly interact with and form signaling complexes with Jak kinases, suggesting that TNF activates a Jak/STAT signal-transduction cascade by acting through TNfr1.
172
DNA Damage Induces NF-κB-dependent MicroRNA-21 Up-regulation and Promotes Breast Cancer Cell Invasion
Jixiao Niu,Yuling Shi,Guangyun Tan,Guangyun Tan,Chuan He Yang,Meiyun Fan,Lawrence M. Pfeffer,Zhao-Hui Wu +7 more
TL;DR: The data support a critical role of DNA damage-induced NF-κB activation in promoting cancer metastasis following genotoxic treatment, and NF-σκB-dependent miR-21 induction may contribute to both therapeutic resistance and metastasis in breast cancer.
161