Christopher R. Calvert
University of California, Los Angeles
8 Papers
39 Citations
Christopher R. Calvert is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: NMDA receptor & Excitatory postsynaptic potential. The author has an hindex of 7, co-authored 8 publications.
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Papers
Transient and Progressive Electrophysiological Alterations in the Corticostriatal Pathway in a Mouse Model of Huntington's Disease
Carlos Cepeda,Raymond S. Hurst,Raymond S. Hurst,Christopher R. Calvert,Elizabeth Hernández-Echeagaray,Oanh Kieu Nguyen,Emily L. Jocoy,Lindsey J. Christian,Marjorie A. Ariano,Michael Levine +9 more
TL;DR: Observations indicate that both progressive and transient alterations occur along the corticostriatal pathway in experimental HD, likely to contribute to the selective vulnerability of striatal medium-sized spiny neurons.
369
NMDA receptor function in mouse models of Huntington disease
Carlos Cepeda,Marjorie A. Ariano,Christopher R. Calvert,Jorge Flores-Hernandez,Scott H. Chandler,Blair R. Leavitt,Michael R. Hayden,Michael Levine +7 more
TL;DR: Findings indicate that alterations in NMDA receptor function may predispose striatal neurons to excitotoxic damage, leading to subsequent neuronal degeneration and underscore the functional importance of NMDA receptors in HD.
303
Dopamine enhancement of NMDA currents in dissociated medium-sized striatal neurons: role of D1 receptors and DARPP-32.
Jorge Flores-Hernandez,Carlos Cepeda,Elizabeth Hernández-Echeagaray,Christopher R. Calvert,Eve S. Jokel,Allen A. Fienberg,Paul Greengard,Michael Levine +7 more
TL;DR: The present findings indicate that the unique potentiation of NMDA receptor function by activation of the D1 receptor signaling cascade can be controlled by multiple mechanisms and has major influences on neuronal function.
290
Morphological and electrophysiological characterization of abnormal cell types in pediatric cortical dysplasia
Carlos Cepeda,Raymond S. Hurst,Jorge Flores-Hernandez,Elizabeth Hernández-Echeagaray,Gloria J. Klapstein,M.K. Boylan,Christopher R. Calvert,Emily L. Jocoy,Oanh Kieu Nguyen,Véronique M. André,Harry V. Vinters,Marjorie A. Ariano,Michael Levine,Gary W. Mathern +13 more
TL;DR: It is concluded that there are cells with abnormal intrinsic membrane properties in pediatric CD, among the four groups of cells, the most abnormal electrophysiological properties were displayed by cytomegalic neurons and large cells with atypical morphology.
196
Striatal potassium channel dysfunction in Huntington's disease transgenic mice.
Marjorie A. Ariano,Carlos Cepeda,Christopher R. Calvert,Jorge Flores-Hernandez,Elizabeth Hernández-Echeagaray,Gloria J. Klapstein,Scott H. Chandler,Neil Aronin,Marian DiFiglia,Michael Levine +9 more
TL;DR: Attenuation in K+ conductances and channel subunit expression contribute to altered electrophysiological properties of MSNs and may partially account for selective cellular vulnerability in the striatum.
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