Christopher Previti
German Cancer Research Center
8 Papers
45 Citations
Christopher Previti is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Deep sequencing & Whole genome sequencing. The author has an hindex of 7, co-authored 8 publications.
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Papers
A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing
Tyler Alioto,Ivo Buchhalter,Sophia Derdak,Barbara Hutter,Matthew D. Eldridge,Eivind Hovig,Lawrence E. Heisler,Timothy Beck,Jared T. Simpson,Laurie Tonon,Anne Sophie Sertier,Ann-Marie Patch,Ann-Marie Patch,Natalie Jäger,Natalie Jäger,Philip Ginsbach,Ruben M. Drews,Nagarajan Paramasivam,Rolf Kabbe,Sasithorn Chotewutmontri,Nicolle Diessl,Christopher Previti,Sabine Schmidt,Benedikt Brors,Lars Feuerbach,Michael Heinold,Susanne Gröbner,Andrey Korshunov,Patrick S. Tarpey,Adam Butler,Jonathan Hinton,David T. Jones,Andrew Menzies,Keiran Raine,Rebecca Shepherd,Lucy Stebbings,Jon W. Teague,Paolo Ribeca,Francesc Castro Giner,Sergi Beltran,Emanuele Raineri,Marc Dabad,Simon Heath,Marta Gut,Robert E. Denroche,Nicholas J. Harding,Takafumi N. Yamaguchi,Akihiro Fujimoto,Hidewaki Nakagawa,Víctor Quesada,Rafael Valdés-Mas,Sigve Nakken,Daniel Vodak,Lawrence Bower,Andy G. Lynch,Charlotte Anderson,Charlotte Anderson,Nicola Waddell,Nicola Waddell,John V. Pearson,John V. Pearson,Sean M. Grimmond,Sean M. Grimmond,Myron Peto,Paul T. Spellman,Minghui He,Cyriac Kandoth,Semin Lee,John Zhang,John Zhang,Louis Letourneau,Singer Ma,Sahil Seth,David Torrents,Liu Xi,David A. Wheeler,Carlos López-Otín,Elias Campo,Peter J. Campbell,Paul C. Boutros,Xose S. Puente,Daniela S. Gerhard,Stefan M. Pfister,Stefan M. Pfister,John Douglas Mcpherson,John Douglas Mcpherson,Thomas J. Hudson,Thomas J. Hudson,Matthias Schlesner,Peter Lichter,Roland Eils,Roland Eils,David T. W. Jones,Ivo Gut +93 more
TL;DR: It is shown that using PCR-free methods and increasing sequencing depth to ∼100 × shows benefits, as long as the tumour:control coverage ratio remains balanced, and many issues are in fact easy to remedy and have an immediate positive impact on mutation detection accuracy.
Next-generation personalised medicine for high-risk paediatric cancer patients – The INFORM pilot study
Barbara C. Worst,Barbara C. Worst,Cornelis M. van Tilburg,Gnana Prakash Balasubramanian,Petra Fiesel,Petra Fiesel,Ruth Witt,Angelika Freitag,Miream Boudalil,Miream Boudalil,Christopher Previti,Stephan Wolf,Sabine Schmidt,Sasithorn Chotewutmontri,Melanie Bewerunge-Hudler,Matthias Schick,Matthias Schlesner,Barbara Hutter,Lenka A. Taylor,Tobias Borst,Christian Sutter,Claus R. Bartram,Till Milde,Till Milde,Elke Pfaff,Elke Pfaff,Andreas E. Kulozik,Arend von Stackelberg,Roland Meisel,Arndt Borkhardt,Dirk Reinhardt,Jan-Henning Klusmann,Gudrun Fleischhack,Stephan Tippelt,Uta Dirksen,Heribert Jürgens,Christof M. Kramm,André O. von Bueren,Frank Westermann,Matthias Fischer,Matthias Fischer,Birgit Burkhardt,Wilhelm Wößmann,Michaela Nathrath,Stefan S. Bielack,Michael C. Frühwald,Simone Fulda,Thomas Klingebiel,Ewa Koscielniak,Matthias Schwab,Matthias Schwab,Roman Tremmel,Roman Tremmel,Pablo Hernáiz Driever,Johannes H. Schulte,Benedikt Brors,Andreas von Deimling,Andreas von Deimling,Peter Lichter,Angelika Eggert,David Capper,David Capper,Stefan M. Pfister,Stefan M. Pfister,David T.W. Jones,Olaf Witt,Olaf Witt +66 more
TL;DR: This study demonstrates the feasibility of comprehensive, real-time molecular profiling for high-risk paediatric cancer patients and expands upon previous personalised oncology endeavors, and presents a model with considerable interest and practical relevance in the burgeoning era of personalised medicine.
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Recurrent MET fusion genes represent a drug target in pediatric glioblastoma
Sebastian Bender,Sebastian Bender,Jan Gronych,Hans-Jörg Warnatz,Barbara Hutter,Susanne Gröbner,Marina Ryzhova,Elke Pfaff,Elke Pfaff,Volker Hovestadt,Florian Weinberg,Sebastian Halbach,Marcel Kool,Paul A. Northcott,Dominik Sturm,Dominik Sturm,Lynn Bjerke,Thomas Zichner,Adrian M. Stütz,Kathrin Schramm,Bingding Huang,Ivo Buchhalter,Michael Heinold,Thomas Risch,Barbara C. Worst,Barbara C. Worst,Cornelis M. van Tilburg,Cornelis M. van Tilburg,Ursula D. Weber,Marc Zapatka,Benjamin Raeder,David Milford,Sabine Heiland,Christof von Kalle,Christopher Previti,Chris Lawerenz,Andreas E. Kulozik,Andreas Unterberg,Olaf Witt,Andreas von Deimling,David Capper,David Capper,Nathalene Truffaux,Nathalene Truffaux,Jacques Grill,Jacques Grill,Nada Jabado,Astrid Sehested,David Sumerauer,Dorra H'mida-Ben Brahim,Saoussen Trabelsi,Ho Keung Ng,David Zagzag,Jeffrey C. Allen,Matthias A. Karajannis,Nicholas G. Gottardo,Chris Jones,Jan O. Korbel,Sabine Schmidt,Stephan Wolf,Guido Reifenberger,Jörg Felsberg,Benedikt Brors,Christel Herold-Mende,Hans Lehrach,Tilman Brummer,Andrey Korshunov,Roland Eils,Marie-Laure Yaspo,Stefan M. Pfister,Peter Lichter,David T.W. Jones +71 more
TL;DR: An integrative genetic analysis of 53 pediatric glioblastomas and five in vitro model systems identified previously unidentified gene fusions involving the MET oncogene, which activated mitogen-activated protein kinase (MAPK) signaling and induced aggressive glial tumors in vivo.
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miR-10a-5p and miR-29b-3p as Extracellular Vesicle-Associated Prostate Cancer Detection Markers.
Thomas Stefan Worst,Thomas Stefan Worst,Christopher Previti,Katja Nitschke,Nicolle Diessl,Julia Christina Gross,Lena Hoffmann,Lisa Frey,Vanessa Thomas,Christoph Kahlert,Karen Bieback,Adriana Torres Crigna,Fabia Fricke,Fabia Fricke,Stefan Porubsky,Niklas Westhoff,Jost von Hardenberg,Philipp Nuhn,Philipp Erben,Maurice Stephan Michel,Michael Boutros +20 more
TL;DR: It is proposed that EV-associatedmiR-10a-5p and miR-29b-3p could serve as potential new PCa detection markers.
Loop-miRs: active microRNAs generated from single-stranded loop regions
Julia Winter,Steffen Link,Dominik Witzigmann,Catherina Hildenbrand,Christopher Previti,Sven Diederichs +5 more
TL;DR: Evidence is provided that precursor-miRNAs can give rise to three distinct endogenous miRNAs: the guide strand, the passenger strand and the loop-miR, which are first evidence that endogenous, unmodified, single-stranded RNA sequences are generated from single-Stranded loop regions of human pre-miRNA hairpins.
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