Christopher Patrick
University of Ottawa
8 Papers
34 Citations
Christopher Patrick is an academic researcher from University of Ottawa. The author has contributed to research in topics: Downregulation and upregulation & Islet. The author has an hindex of 6, co-authored 7 publications. Previous affiliations of Christopher Patrick include Ottawa Hospital Research Institute.
Chat about Author
Papers
Promotion of Autoimmune Diabetes by Cereal Diet in the Presence or Absence of Microbes Associated With Gut Immune Activation, Regulatory Imbalance, and Altered Cathelicidin Antimicrobial Peptide
Christopher Patrick,Christopher Patrick,Gen-Sheng Wang,David E. Lefebvre,David E. Lefebvre,Jennifer A. Crookshank,Brigitte Sonier,Chandra Eberhard,Chandra Eberhard,Majid Mojibian,Majid Mojibian,Chris R. J. Kennedy,Chris R. J. Kennedy,Stephen P. J. Brooks,Martin Kalmokoff,Mariantonia Maglio,Riccardo Troncone,Philippe Poussier,Fraser W. Scott,Fraser W. Scott +19 more
TL;DR: A cereal diet was a stronger promoter of T1D than gut microbes in association with impaired gut immune homeostasis.
63
Increased islet neogenesis without increased islet mass precedes autoimmune attack in diabetes-prone rats.
Lisa Marie Kauri,Gen-Sheng Wang,Christopher Patrick,Mirella Bareggi,David J. Hill,Fraser W. Scott +5 more
TL;DR: The results suggest that despite increased islet neogenesis, the capacity for islet expansion in diabetes-prone rats is compromised possibly due to decreased proliferative capacity with increasing islet size associated with a partial block at the G1/S cell cycle boundary in islet cells.
23
Changes in insulin, glucagon and ER stress precede immune activation in type 1 diabetes
Jennifer A. Crookshank,Daniel Serrano,Gen-Sheng Wang,Christopher Patrick,Christopher Patrick,Baylie S Morgan,Baylie S Morgan,Marie-France Paré,Fraser W. Scott,Fraser W. Scott,Fraser W. Scott +10 more
TL;DR: It is proposed that dysregulated metabolism leads to ER stress in neonatal rats long before insulitis, creating a microenvironment in both pancreas and liver that promotes autoimmunity.
Neuroprotection in neurodegenerations of the brain and eye: Lessons from the past and directions for the future
TL;DR: The common features of neurological and ophthalmological neurodegenerations are useful for outlining a path forward that should increase the likelihood of translational success in neuroprotective therapies.