Christopher P. Lapointe

TL;DR: A mechanism for post-transcriptionally coordinating CoQ production with OxPhos biogenesis is revealed, and the power of multi-omics for defining genuine targets of RBPs is demonstrated.

TL;DR: The results showed that although RNA-binding proteins productively bind specific RNAs to control their function, they also 'sample' RNAs without exerting a regulatory effect.

TL;DR: Single-molecule dynamics reveal that the GTPase activity of eukaryotic initiation factor eIF5B serves as a kinetic checkpoint for the transition from translation initiation to elongation, and how its release may be governed by a change in the conformation of the ribosome complex that triggers GTP hydrolysis.

TL;DR: TRAID-seq is developed, a screening strategy in Saccharomyces cerevisiae to identify sequences added to a reporter RNA at single-nucleotide resolution by overexpressed candidate enzymes from different organisms that proposes that MUT-2 poly(UG) polymerase activity is required to promote genome integrity and RNA silencing.