Christopher Morehouse
AstraZeneca
4 Papers
Christopher Morehouse is an academic researcher from AstraZeneca. The author has contributed to research in topics: Biology & Microbiome. The author has an hindex of 2, co-authored 4 publications.
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Papers
Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis.
Arpan Sharma Neupane,Michelle Elizabeth Willson,Andrew Chojnacki,Fernanda Vargas E Silva Castanheira,Christopher Morehouse,Agostina Carestia,Ashley E. Keller,Moritz Peiseler,Antonio DiGiandomenico,Margaret M. Kelly,Matthias Amrein,Craig N. Jenne,Ajitha Thanabalasuriar,Paul Kubes +13 more
TL;DR: In a disease context, influenza A virus infection impaired AM crawling via the type II interferon signaling pathway, and this greatly increased secondary bacterial co-infection, leading to inappropriate inflammation and injury.
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Safety and clinical activity of intratumoral MEDI9197 alone and in combination with durvalumab and/or palliative radiation therapy in patients with advanced solid tumors.
Lillian L. Siu,Joshua Brody,Shilpa Gupta,Aurélien Marabelle,Antonio Jimeno,Pamela N. Munster,Juneko E. Grilley-Olson,Alain H. Rook,Antoine Hollebecque,Rebecca Wong,James W. Welsh,Yuling Wu,Christopher Morehouse,Oday Hamid,Farzana Walcott,Zachary A. Cooper,Rakesh Kumar,Charles Ferté,David S. Hong +18 more
TL;DR: Although no patients responded, MEDI9197 induced systemic and intratumoral immune activation, indicating potential value in combination regimens in other patient populations, and was feasible for subcutaneous/cutaneous lesions but AEs precluded its use in deep-seated lesions.
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PD-L1 + neutrophils contribute to injury-induced infection susceptibility.
Ajitha Thanabalasuriar,Ajitha Thanabalasuriar,Abby J. Chiang,Christopher Morehouse,Margarita Camara,Shonda Hawkins,Ashley E. Keller,Adem C. Koksal,Carolina S. Caceres,Aaron A Berlin,Nicholas Holoweckyj,Virginia N. Takahashi,Lily Cheng,Melissa de los Reyes,Mark Pelletier,Andriani C. Patera,Bret R. Sellman,Sonja Hess,Marcello Marelli,Chelsea C. Boo,Taylor S. Cohen,Antonio DiGiandomenico +21 more
TL;DR: In this article, the authors describe a rapid increase in neutrophil cell numbers in the lungs following induction of thermal injury, indicating that injury promotes changes to neutrophils that are important for wound healing but contribute to infection susceptibility.
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Engraftment of Bacteria after Fecal Microbiota Transplantation Is Dependent on Both Frequency of Dosing and Duration of Preparative Antibiotic Regimen
Vancheswaran Gopalakrishnan,Elizabeth Ashley Dozier,Matthew S. Glover,Steven Novick,Mike Ford,Christopher Morehouse,Paul Warrener,Carolina S. Caceres,Sonja Hess,Bret R. Sellman,Taylor S. Cohen +10 more
- 29 Jun 2021
TL;DR: In this article, the authors used 16S ribosomal RNA (rRNA) sequencing and liquid chromatography-mass spectrometry (LC-MS) profiling of fecal samples.
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