Christopher Mitchell
Takeda Pharmaceutical Company
13 Papers
4 Citations
Christopher Mitchell is an academic researcher from Takeda Pharmaceutical Company. The author has contributed to research in topics: Heat transfer & Impeller. The author has an hindex of 4, co-authored 8 publications.
Chat about Author
Papers
Development and Scale-up of an Efficient Miyaura Borylation Process Using Tetrahydroxydiboron
Sing R. Gurung,Christopher Mitchell,Jie Huang,Marco Jonas,Josiah D. Strawser,Elena Daia,Andrew Hardy,Erin O’Brien,Frederick Hicks,Charles D. Papageorgiou +9 more
TL;DR: In this paper, a revised Miyaura borylation process was developed using tetrahydroxydiboron that avoids the use of bis(pinacolato) diborons and hence the need to hydrolyze the resulting boronic ester to its corresponding acid.
40
Development of Suitable Plant-Scale Drying Conditions That Prevent API Agglomeration and Dehydration
Julie Adamson,Neil Faiber,Alex Gottlieb,Lexi Hamsmith,Frederick Hicks,Christopher Mitchell,Bhavi Mittal,Kouji Mukai,Charles D. Papageorgiou +8 more
TL;DR: In this article, a scale down agitated filter dryer was designed that was used to study the drying unit operation and identify key process parameters, and suitable drying conditions were developed that minimized agglomeration, eliminated dehydration, and produced API that behaved acceptably in downstream drug product (DP) manufacture.
24
Investigation of wet milling and indirect ultrasound as means for controlling nucleation in the continuous crystallization of an active pharmaceutical ingredient
Yihui Yang,Bilal Ahmed,Bilal Ahmed,Christopher Mitchell,Justin L. Quon,Humera Siddique,Ian Houson,Alastair J. Florence,Charles D. Papageorgiou +8 more
TL;DR: In this paper, the authors compared the use of wet milling and indirect ultrasound for promoting nucleation and controlling the particle size during the continuous crystallization of a hard-to-nucleate active pharmaceutical ingredient (API).
13
Development of a Modeling-Based Strategy for the Safe and Effective Scale-up of Highly Energetic Hydrogenation Reactions
Christopher Mitchell,Josiah D. Strawser,Alex Gottlieb,Michael H. Millonig,Frederick Hicks,Charles D. Papageorgiou +5 more
TL;DR: In this paper, a modeling-based strategy is disclosed for identifying reaction conditions for the safe and effective scale-up of highly energetic hydrogenation reactions. The model was developed within Scale-up Systems’s DynoChem 2011 and takes under consideration the kinetics of the reaction, the reactor heat transfer capabilities, and the degree of mass transfer.
6