Christopher M. Chambers
University of South Florida
11 Papers
134 Citations
Christopher M. Chambers is an academic researcher from University of South Florida. The author has contributed to research in topics: HMG-CoA reductase & Reductase. The author has an hindex of 10, co-authored 11 publications.
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Papers
Feedback and hormonal regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase: the concept of cholesterol buffering capacity.
TL;DR: High basal expression of hepatic HMG-CoA reductase, whether due to genetic or hormonal factors, appears to result in greater cholesterol buffering capacity and thus increased resistance to dietary cholesterol.
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Atorvastatin action involves diminished recovery of hepatic HMG-CoA reductase activity
TL;DR: The results support the conclusion that the potent hypocholesterolemic action of atorvastatin involves decreased hepatic VLDL production due to effective inhibition of in vivo cholesterol biosynthesis resulting from diminished recovery of HMG-CoA reductase activity following drug treatment.
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Farnesol Is Not the Nonsterol Regulator Mediating Degradation of HMG-CoA Reductase in Rat Liver
TL;DR: Observations indicate that farnesol per se does not induce accelerated degradation of HMG-CoA reductase in rat liver and that intubation of rats with 500 mg/kg body wt of farNESol failed to decrease the half-life of H MG- coenzyme A reduct enzyme protein, alter the levels of enzyme activity, or change of the Levels of immunoreactive protein.
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Translational Regulation of Hepatic HMG-CoA Reductase by Dietary Cholesterol
TL;DR: Findings indicate that dietary cholesterol exerts significant feedback regulation on hepatic HMG-CoA reductase at the translational level.
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Esophagography predicts favorable outcomes after laparoscopic Nissen fundoplication for patients with esophageal dysmotility.
Matthew J. D’Alessio,Steven Rakita,Mark Bloomston,Christopher M. Chambers,Emmanuel E. Zervos,Steven B. Goldin,Jerry Poklepovic,H. Worth Boyce,Alexander S. Rosemurgy +8 more
TL;DR: Patients with esophageal dysmotility documented by manometry who are able to clear a food bolus at contrast esophagography, have functional results after laparoscopic Nissen fundoplication similar to patients with normal motility.
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