Christopher Laver
University of British Columbia
8 Papers
83 Citations
Christopher Laver is an academic researcher from University of British Columbia. The author has contributed to research in topics: Transplantation & Embryoid body. The author has an hindex of 7, co-authored 8 publications.
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Papers
Differentiation of human embryonic stem cells using size-controlled embryoid bodies and negative cell selection in the production of photoreceptor precursor cells.
Anat Yanai,Christopher Laver,Aaron W. Joe,Ishaq A. Viringipurampeer,Xia Wang,Cheryl Y. Gregory-Evans,Kevin Gregory-Evans +6 more
TL;DR: Improved efficiency of PPC production will help in efforts to undertake shorter and larger preclinical studies as a prelude to future clinical trials, and could be increased to 93% PPCs through the added step of negative cell selection.
Enhanced functional integration of human photoreceptor precursors into human and rodent retina in an ex vivo retinal explant model system.
TL;DR: The utility of an ex vivo model system to define factors, such as TSP-1, which could influence integration efficiency in future in vivo experiments in models of retinal degeneration are demonstrated.
Efficient Production of Photoreceptor Precursor Cells from Human Embryonic Stem Cells.
TL;DR: This novel protocol produces higher yields of PPCs than previously reported while reducing the time required for differentiation, which will help understand retinal diseases and facilitate large-scale preclinical trials.
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Structural divergence of essential triad ribbon synapse proteins among placental mammals - Implications for preclinical trials in photoreceptor transplantation therapy.
TL;DR: A dual role after cleavage is suggested for pikachurin where the N‐terminal fragment can still mediate the trans‐synaptic bridge, while the C‐ terminal fragment may act as a diffusible trophic or “homing” factor for bipolar cell dendrite migration.
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