Christopher Foley
University of Arizona
13 Papers
81 Citations
Christopher Foley is an academic researcher from University of Arizona. The author has contributed to research in topics: Isocyanide & Azide. The author has an hindex of 8, co-authored 12 publications.
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Papers
Dyrk1 inhibition improves Alzheimer's disease-like pathology
Caterina Branca,Darren M. Shaw,Ramona Belfiore,Ramona Belfiore,Vijay Gokhale,Arthur Y. Shaw,Christopher Foley,Breland Smith,Christopher Hulme,Travis Dunckley,Bessie Meechoovet,Antonella Caccamo,Salvatore Oddo +12 more
TL;DR: It is found that chronic Dyrk1 inhibition reversed cognitive deficits in 3xTg‐AD mice and was associated with a reduction in amyloid‐β (Aβ) and tau pathology.
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Exploring Ugi-Azide Four-Component Reaction Products for Broad-Spectrum Influenza Antivirals with a High Genetic Barrier to Drug Resistance.
Jiantao Zhang,Yanmei Hu,Christopher Foley,Yuanxiang Wang,Rami Musharrafieh,Shuting Xu,Yongtao Zhang,Chunlong Ma,Christopher Hulme,Jun Wang +9 more
TL;DR: The discovery of compound 12a as a broad-spectrum influenza antiviral with a high in vitro genetic barrier to drug resistance is significant, as it offers a second line of defense to combat the next influenza epidemics and pandemics if vaccines and oseltamivir fail to confine the disease outbreak.
Aza-Riley Oxidation of Ugi-Azide and Ugi-3CR Products toward Vicinal Tricarbonyl Amides: Two-Step MCR-Oxidation Methodology Accessing Functionalized α,β-Diketoamides and α,β-Diketotetrazoles
TL;DR: This significant extension of the previously described multicomponent reaction-oxidative deamination methodology is proposed to proceed through a mechanistically distinct SeO2-mediated C-N oxidation derived from an active enol of α-amino-β-ketone systems, effectively an aza-Riley oxidation.
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Two-Step Route to Diverse N-Functionalized Peptidomimetic-like Isatins through an Oxidation/Intramolecular Oxidative-Amidation Cascade of Ugi Azide and Ugi Three-Component Reaction Products.
TL;DR: The two-step methodology described herein showcases the first example of an oxidation/oxidative amidation cyclization cascade of MCR products toward diverse N-functionalized isatins containing multiple points of diversification.
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Synthesis of fluorescent heterocycles via a Knoevenagel/[4 + 1]-cycloaddition cascade using acetyl cyanide.
Guillermo Martinez-Ariza,Bereketab T. Mehari,Ludmila A.G. Pinho,Christopher Foley,Kendall Day,John C. Jewett,Christopher Hulme +6 more
TL;DR: A concise one-pot three-component reaction that affords fluorescent indolizines, benzo[d]pyrrolo[2,1-b]thiazoles, and pyrrola[1,2-a]pyrazines is reported.
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