Christopher E. Randolph
12 Papers
9 Citations
Christopher E. Randolph is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 6 publications.
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Papers
Human Milk Oligosaccharides Impact Cellular and Inflammatory Gene Expression and Immune Response
Fernanda Schulz da Rosa,Ashok K. Sharma,Manoj Gurung,David Casero,Katelin S Matazel,Lars Bode,Christine M Simecka,Ahmed A. Elolimy,Patricia Tripp,Christopher E. Randolph,Timothy W. Hand,Keith Williams,Tanya LeRoith,Laxmi Yeruva +13 more
TL;DR: The data suggest that HMOs have a direct effect on gastrointestinal tract metabolism and the immune system even in the absence of host microbiota.
Nox4 expression in osteo-progenitors controls bone development in mice during early life
Jin-Ran Chen,Oxana P. Lazarenko,Michael R. Blackburn,Jennifer F. Chen,Christopher E. Randolph,Jovanny Zabaleta,K. Schroder,Kim Brint Pedersen,Martin J. J. Ronis +8 more
TL;DR: In this paper , the role of Nox4 in osteo-progenitors during postnatal bone development was investigated in both sexes, and the results showed that under-developed bone formation in 3-week old CKO and Nox-4-/- mice quickly caught up to levels of control mice by 6-week of age, remained no different at 13-week-of age, and was reversed in 32-week older male mice compared with control mice.
Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
Kevin Chappell,Kanishka Manna,Charity L. Washam,Stefan Graw,Stefan Graw,Duah Alkam,Matthew D. Thompson,Maroof K. Zafar,Lindsey Hazeslip,Christopher E. Randolph,Allen Gies,Jordan T. Bird,Alicia K. Byrd,Sayem Miah,Stephanie D. Byrum +14 more
- 11 Oct 2021
TL;DR: In this paper, a multi-omics data integration method was applied to evaluate the correlation of important regulatory features in triple negative breast cancer (TNBC) cells compared with non-tumorigenic epithelial breast MCF10A cells.
Formula Diet Alters the Ileal Metagenome and Transcriptome at Weaning and during the Postweaning Period in a Porcine Model.
Ahmed A. Elolimy,Charity L. Washam,Stephanie D. Byrum,Celine Chen,Harry D. Dawson,Anne K. Bowlin,Christopher E. Randolph,Manish Kumar Saraf,Laxmi Yeruva +8 more
- 25 Aug 2020
TL;DR: Exclusive breastfeeding impacts the intestinal microbiome and is associated with a better immune function than is seen with milk formula (MF) feeding in infants and yet with mechanisms poorly defined, the first insight into MF-microbiome-inflammation connections in the small intestine compared with HM feeding using a porcine model is provided.
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Mapping methylation quantitative trait loci in cardiac tissues nominates risk loci and biological pathways in congenital heart disease.
Ming Li,Chen Lyu,Manyan Huang,Catherine Do,Benjamin Tycko,Philip J. Lupo,Stewart L. MacLeod,Christopher E. Randolph,Nianjun Liu,John S. Witte,Charlotte A. Hobbs +10 more
- 10 Jun 2021
TL;DR: In this article, the authors investigated the effects of genetic single nucleotide polymorphisms (SNPs) on local DNA methylation patterns within 83 cardiac tissue samples and prioritized their contributions to CHD risk by leveraging results of CHD genome-wide association studies (GWAS) and their effects on cardiac gene expression.