Christopher Dennison
Newcastle University
101 Papers
1.1K Citations
Christopher Dennison is an academic researcher from Newcastle University. The author has contributed to research in topics: Azurin & Amicyanin. The author has an hindex of 31, co-authored 97 publications. Previous affiliations of Christopher Dennison include California Institute of Technology & University of Newcastle.
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Papers
Protein-folding location can regulate manganese-binding versus copper- or zinc-binding
Steve Tottey,Kevin J. Waldron,Susan J. Firbank,Brian Reale,Conrad Bessant,Katsuko Sato,Timothy R. Cheek,Joe Gray,Mark J. Banfield,Christopher Dennison,Nigel J. Robinson +10 more
TL;DR: Results reveal a mechanism whereby the compartment in which a protein folds overrides its binding preference to control its metal content, and explain why the cytoplasm must contain only tightly bound and buffered copper and Zn2+.
337
Investigating the structure and function of cupredoxins
TL;DR: This review will describe some of the recent advances that have been made in protein engineering combined with various spectroscopic and kinetic approaches, highlighting that there is still a long way to go before the authors fully appreciate the complexity of biological electron transfer proteins.
152
Methanobactin and the Link between Copper and Bacterial Methane Oxidation
Alan A. DiSpirito,Jeremy D. Semrau,J. Colin Murrell,Warren H. Gallagher,Christopher Dennison,Stéphane Vuilleumier +5 more
TL;DR: The current state of knowledge of this novel type of metal-binding peptide, Methanobactins, is examined, which explores its potential applications, how mbs may alter the bioavailability of multiple metals, and the many roles mb may play in the physiology of methanotrophs.
138
Introduction of a CuA site into the blue copper protein amicyanin from Thiobacillus versutus
TL;DR: Recent evidence strongly suggests that the CuA centre of cytochrome c oxidase and the A centre of nitrous oxide reductase are similar and are both binuclear, so it follows that the purple amicyanin mutant created here also possesses a binuclear CuA center.
89
Spectroscopic and Electrochemical Studies on Active-site Transitions of the Type 1 Copper Protein Pseudoazurin from Achromobacter cycloclastes
Takamitsu Kohzuma,Christopher Dennison,William McFarlane,Satoru Nakashima,Teizo Kitagawa,Tsuyoshi Inoue,Yasushi Kai,Nobuya Nishio,Sohsuke Shidara,Shinnichiro Suzuki,A. Geoffrey Sykes +10 more
TL;DR: The single type 1 copper protein pseudoazurin from Achromobacter cycloclastes gives reversible electrochemical behavior at a (4-pyridyl)disulfide-modified gold electrode, which indicates a conversion of the distorted tetrahedral copper geometry to a trigonal structure.
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