Christopher D. Putnam
University of California, San Diego
87 Papers
906 Citations
Christopher D. Putnam is an academic researcher from University of California, San Diego. The author has contributed to research in topics: DNA mismatch repair & DNA repair. The author has an hindex of 40, co-authored 80 publications. Previous affiliations of Christopher D. Putnam include Washington University in St. Louis & University of California, Los Angeles.
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Papers
X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution.
TL;DR: In this article, a review of the use of small angle X-ray scattering (SAXS) for modeling macromolecular folding, unfolding, aggregation, extended conformations, flexibly linked domains, shape, conformation, and assembly state in solution, albeit at the lower resolution range of about 50 A to 10 A resolution, is presented.
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Maintenance of genome stability in Saccharomyces cerevisiae.
TL;DR: Human homologs of several of these genes have well-established roles as tumor suppressors, consistent with the hypothesis that the mechanisms preserving genome stability in yeast are the same mechanisms that go awry in cancer.
510
Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism.
TL;DR: These resting state and inhibited humanCatalase structures support specific, structure-based mechanisms for the catalase substrate recognition, reaction and inhibition and provide a molecular basis for understanding ethanol intoxication and the likely effects of human polymorphisms.
475
The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model.
Ivona Aksentijevich,Christopher D. Putnam,Elaine F. Remmers,James L. Mueller,Julie Le,Richard D. Kolodner,Zachary Moak,Michael Chuang,Frances Austin,Raphaela Goldbach-Mansky,Hal M. Hoffman,Daniel L. Kastner +11 more
TL;DR: Investigation of the structural effect of disease-causing mutations on cryopyrin provides insight into potential molecular mechanisms by which cryopyrsin mutations can inappropriately activate an inflammatory response.
413
Inflammasome-Mediated Disease Animal Models Reveal Roles for Innate but Not Adaptive Immunity
Susannah Brydges,Susannah Brydges,James L. Mueller,James L. Mueller,Matthew D. McGeough,Carla A. Peña,Amirhossein Misaghi,Chhavi Gandhi,Christopher D. Putnam,Christopher D. Putnam,David L. Boyle,Gary S. Firestein,Anthony A. Horner,Pejman Soroosh,Wendy T. Watford,John J. O'Shea,Daniel L. Kastner,Hal M. Hoffman +17 more
TL;DR: It is suggested that CAPS are true inflammasome-mediated diseases and provide insight for more common inflammatory disorders.
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