Christopher Church
AstraZeneca
8 Papers
Christopher Church is an academic researcher from AstraZeneca. The author has contributed to research in topics: Adipose tissue & Insulin resistance. The author has an hindex of 4, co-authored 8 publications. Previous affiliations of Christopher Church include MedImmune.
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Papers
Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis.
Anna Whitehead,Fynn N. Krause,Amy Moran,Amanda D. V. MacCannell,Jason L. Scragg,Ben D. McNally,Edward Boateng,Steven A. Murfitt,Samuel Virtue,John Wright,Jack Garnham,Graeme Davies,James Dodgson,Jürgen E. Schneider,Andrew J. Murray,Christopher Church,Antonio Vidal-Puig,Klaus K. Witte,Julian L. Griffin,Lee D. Roberts +19 more
TL;DR: This article identified 3-methyl-2-oxovaleric acid, 5-oxoproline, and β-hydroxyisobutyric acid as small molecule metabokines synthesized in browning adipocytes and secreted via monocarboxylate transporters.
The role of adipokines in skeletal muscle inflammation and insulin sensitivity
TL;DR: The mechanism of action and function of adipokines in mediating insulin sensitivity in skeletal muscle may lead to the development of novel therapeutics for patients with type 2 diabetes, but to date studies conducted in human skeletal muscle cells and tissues are limited.
The Novel Adipokine Gremlin 1 Antagonizes Insulin Action and Is Increased in Type 2 Diabetes and NAFLD/NASH
Shahram Hedjazifar,Roxana Khatib Shahidi,Ann Hammarstedt,Laurianne Bonnet,Christopher Church,Jeremie Boucher,Jeremie Boucher,Matthias Blüher,Ulf Smith +8 more
TL;DR: Gremlin 1 is a novel secreted insulin antagonist and biomarker as well as a potential therapeutic target in obesity and its complications T2D and NAFLD/NASH.
Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation.
TL;DR: A role for AKAP1 in thermogenesis, uncoupled respiration, and regulation energy balance is highlighted, and a family of compounds that increase UCP1 expression and mitochondrial activity are identified in mouse brown adipocytes and human brown and white adipocytes.
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Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the liver.
Roxana Khatib Shahidi,Jenny M. Hoffmann,Shahram Hedjazifar,Laurianne Bonnet,Ritesh K. Baboota,Stephanie Heasman,Christopher Church,Ivet Elias,Fatima Bosch,Jeremie Boucher,Jeremie Boucher,Ann Hammarstedt,Ulf Smith +12 more
TL;DR: In this paper, the authors examined the effects of AAV8 vectors expressing GREM1 in the liver or receiving regular intra-peritoneal injections of recombinant GREM 1 protein.