Christopher C. Nawrat
Merck & Co.
8 Papers
11 Citations
Christopher C. Nawrat is an academic researcher from Merck & Co.. The author has contributed to research in topics: Chemistry & Nucleoside. The author has an hindex of 4, co-authored 8 publications.
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Papers
Design of an in vitro biocatalytic cascade for the manufacture of islatravir
Mark A. Huffman,Anna Fryszkowska,Oscar Alvizo,Margie Borra-Garske,Kevin R. Campos,Canada Keith A,Paul N. Devine,Da Duan,Jacob Forstater,Shane T. Grosser,Holst M. Halsey,Gregory Hughes,Junyong Jo,Leo A. Joyce,Joshua N. Kolev,Jack Liang,Kevin M. Maloney,Benjamin F. Mann,Nicholas M. Marshall,Mark McLaughlin,Jeffrey C. Moore,Grant S. Murphy,Christopher C. Nawrat,Jovana Nazor,Scott J. Novick,Niki R. Patel,Agustina Rodriguez-Granillo,Sandra A. Robaire,Edward C. Sherer,Matthew D. Truppo,Aaron M. Whittaker,Deeptak Verma,Li Xiao,Yingju Xu,Hao Yang +34 more
TL;DR: An in vitro biocatalytic cascade synthesis of the investigational HIV treatment islatravir is reported, requiring fewer than half the number of steps of the previously reported routes.
492
Beyond optical rotation: what's left is not always right in total synthesis
Leo A. Joyce,Christopher C. Nawrat,Edward C. Sherer,Mirlinda Biba,Andrew Brunskill,Gary E. Martin,Ryan D. Cohen,Ian W. Davies +7 more
TL;DR: In this article, the authors used vibrational (VCD) and electronic (ECD) circular dichroism spectroscopy to solve the longstanding debate around the absolute configuration of (+)-frondosin B (1).
Synthesis of Islatravir Enabled by a Catalytic, Enantioselective Alkynylation of a Ketone
Niki R. Patel,Christopher C. Nawrat,Mark McLaughlin,Yingju Xu,Mark A. Huffman,Hao Yang,Hongming Li,Aaron M. Whittaker,Teresa Andreani,François Lévesque,Anna Fryszkowska,Andrew Brunskill,David M. Tschaen,Kevin M. Maloney +13 more
TL;DR: The synthesis of the potent anti-HIV investigational treatment islatravir is described and a rare example of the asymmetric addition of an alkyne nucleophile to a ketone through ligand-accelerated catalysis that was performed on a greater than 100 g scale is described.
25
Synthesis of Isotopically Labeled Anti-HIV Nucleoside Islatravir through a One-Pot Biocatalytic Cascade Reaction
Sumei Ren,Mark A. Huffman,Aaron M. Whittaker,Hao Yang,Christopher C. Nawrat,David J. Waterhouse,Kevin M. Maloney,Neil A. Strotman +7 more
TL;DR: The synthesis of the carbon-14-labeled unnatural nucleoside islatravir, an investigational HIV drug, through a one-pot biocatalytic cascade starting from acetaldehyde-2-14C is reported.
7
Development of an Efficient Route to 2-Ethynylglycerol for the Synthesis of Islatravir
Rummelt Sm,Qi J,Chen Y,Dropinski Jf,Gregory Hughes,Kuethe Jt,Li D,Kevin M. Maloney,Margelefsky E,Mathew R,Muzzio Dj,Christopher C. Nawrat,Justin A. Newman,Ouyang H,Niki R. Patel,Qiao Z,Shang G,Eric B. Sirota,Song Zj,Tan L,Varsolona Rj,Wan B,Wyvratt Bm,Xu F,Yingju Xu,Yin J,Zhang S,Zhao R +27 more
TL;DR: The development of an efficient synthesis of this unnatural, alkyne-containing nucleoside analog islatravir is described including the initial route, route scouting and final process development.