Christopher C. Farnsworth
University of Washington
20 Papers
998 Citations
Christopher C. Farnsworth is an academic researcher from University of Washington. The author has contributed to research in topics: Prenylation & Rab. The author has an hindex of 15, co-authored 20 publications. Previous affiliations of Christopher C. Farnsworth include Jules Stein Eye Institute.
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Papers
Prenyl proteins in eukaryotic cells: a new type of membrane anchor
TL;DR: This work has indicated that eukaryotic cells contain proteins that are post-translationally modified by long-chain, thioether-linked prenyl groups, which appears to initiate a set of additional protein modification reactions that promote attachment of the proteins to specific membranes.
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Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye
Mark A Kanow,Michelle M. Giarmarco,Connor Jankowski,Kristine Tsantilas,Abbi L. Engel,Jianhai Du,Jonathan D. Linton,Christopher C. Farnsworth,Stephanie R. Sloat,Austin M. Rountree,Ian R. Sweet,Ken J. Lindsay,Ken J. Lindsay,Edward D Parker,Susan E. Brockerhoff,Martin Sadilek,Jennifer R Chao,James B. Hurley +17 more
TL;DR: It is shown that lactate can suppress consumption of glucose by the retinal pigment epithelium, and this framework for understanding metabolic relationships in the vertebrate retina provides new insights into the underlying causes of retinal disease and age-related vision loss.
Human Lamin B Contains a Farnesylated Cysteine Residue
TL;DR: The modified amino acid is identified, its mode of linkage to the mevalonic acid derivative is determined, its structure is established, and the thioether-modified cysteine residue is established.
335
Brain G protein gamma subunits contain an all-trans-geranylgeranylcysteine methyl ester at their carboxyl termini.
Harvey K. Yamane,Christopher C. Farnsworth,Hongying Xie,William Howald,Bernard K.-K. Fung,Steven Clarke,Michael H. Gelb,John A. Glomset +7 more
TL;DR: The results demonstrate that at least two forms of brain gamma subunit are posttranslationally modified by geranylgeranylation and carboxyl methylation, which may be important for targeting G beta gamma complexes to membranes.
232
Identification of Geranylgeranyl-Modified Proteins in HeLa Cells
TL;DR: In the present study, a novel isoprenoid-modification was identified by labeling HeLa cells with [3H]mevalonic acid and analyzing proteolytic digests of the total cell protein, revealing an all-trans geranylgeranyl group was a major isopranoid modification.