Christophe Joubert
French Institute of Health and Medical Research
5 Papers
18 Citations
Christophe Joubert is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Genetic enhancement & Hematopoietic stem cell transplantation. The author has an hindex of 4, co-authored 4 publications.
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Papers
Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages
Karine Labadie,Thibaut Larcher,Christophe Joubert,Abdelkrim Mannioui,Benoit Delache,Patricia Brochard,Lydie Guigand,Laurence Dubreil,Pierre Lebon,Bernard Verrier,Xavier de Lamballerie,Andreas Suhrbier,Yan Cherel,Roger Le Grand,Pierre Roques +14 more
TL;DR: In the macaques, long-term CHIKV infection was observed in joints, muscles, lymphoid organs, and liver, which could explain the long-lasting CHikV disease symptoms observed in humans.
Preclinical Evaluation of Efficacy and Safety of an Improved Lentiviral Vector for the Treatment of β-Thalassemia and Sickle Cell Disease
Olivier Negre,Cynthia C. Bartholomae,Yves Beuzard,Marina Cavazzana,Lauryn Christiansen,Celine Courne,Annette Deichmann,Maria Denaro,Edouard de Dreuzy,Mitchell Finer,Raffaele Fronza,Beatrix Gillet-Legrand,Christophe Joubert,Robert H. Kutner,Philippe Leboulch,Philippe Leboulch,Leila Maouche,Anais Paulard,Francis J. Pierciey,Michael Rothe,Byoung Y. Ryu,Manfred Schmidt,Christof von Kalle,Emmanuel Payen,Gabor Istvan Veres +24 more
TL;DR: This comprehensive efficacy and safety data provided the basis for initiating two clinical trials with this second generation vector (BB305) in Europe and in the USA in patients with β-thalassemia major and sickle cell disease.
Stem cell factor-displaying simian immunodeficiency viral vectors together with a low conditioning regimen allow for long-term engraftment of gene-marked autologous hematopoietic stem cells in macaques.
Els Verhoeyen,Francis Relouzat,Marie Cambot,Caroline Costa,Didier Nègre,Faézeh Legrand,Christophe Joubert,Roger Le Grand,François-Loïc Cosset,Philippe Leboulch,Anne Dubart-Kupperschmitt,Stéphane Prost +11 more
TL;DR: Fludarabine together with low-level total body irradiation and the use of a stem cell factor-displaying simian immunodeficiency virus-based vector resulted in sustained, single-copy vector marking of autologous blood cells in two macaques over 3 years posttransplantation, which is within the range of anticipated efficacy levels for hemophilia and related diseases and forms a basis for further improvement.
Disseminated sparganosis in a cynomolgus macaque (Macaca fascicularis).
A.-L. Bauchet,Christophe Joubert,J.-M. Helies,S.A. Lacour,Nathalie Bosquet,R Le Grand,Jacques Guillot,F. Lachapelle +7 more
TL;DR: An adult male cynomolgus macaque from Mauritius arrived at the authors' facility in France after a 1-year period of quarantine in Spain with the presence of numerous firm cutaneous and subcutaneous nodules, and persistent mild eosinophilia.
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Multi-component prime-boost Chlamydia trachomatis vaccination regimes induce antibody and T cell responses and accelerate clearance of infection in a non-human primate model
Emma Lorenzen,Vanessa Contreras,Anja Olsen,Peter Andersen,Delphine Desjardins,Ida Rosenkrands,Helene B Juel,Benoit Delache,Sébastien Langlois,Constance Delaugerre,Christophe Joubert,Nathalie Dereuddre-Bosquet,Cécile Bébéar,Bertille de Barbeyrac,Arabella Touati,Paul F. McKay,Robin J. Shattock,Roger Le Grand,Frank Follmann,Jes Dietrich +19 more
TL;DR: In this paper , the authors evaluated immunization strategies in a nonhuman primate (NHP) model and found that the recombinant protein antigen (CTH522) vaccinated groups established a multifunctional CD4 T cell response, whereas the DNA and Vector vaccinated groups also established a CD8 T cells response.