Christoph Slavetinsky
University of Tübingen
21 Papers
2 Citations
Christoph Slavetinsky is an academic researcher from University of Tübingen. The author has contributed to research in topics: Flippase & Medicine. The author has an hindex of 8, co-authored 13 publications. Previous affiliations of Christoph Slavetinsky include Boston Children's Hospital.
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Papers
Human commensals producing a novel antibiotic impair pathogen colonization
Alexander Zipperer,Martin C. Konnerth,Claudia Laux,Anne Berscheid,Daniela Janek,Daniela Janek,Christopher Weidenmaier,Marc Burian,Nadine A. Schilling,Christoph Slavetinsky,Matthias Marschal,Matthias Willmann,Hubert Kalbacher,Birgit Schittek,Heike Brötz-Oesterhelt,Stephanie Grond,Andreas Peschel,Bernhard Krismer +17 more
TL;DR: It is shown that nasal Staphylococcus lugdunensis strains produce lugdunin, a novel thiazolidine-containing cyclic peptide antibiotic that prohibits colonization by S. aureus, and a rare example of a non-ribosomally synthesized bioactive compound from human-associated bacteria.
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Gain-of-Function Mutations in the Phospholipid Flippase MprF Confer Specific Daptomycin Resistance
Christoph M. Ernst,Christoph Slavetinsky,Christoph Slavetinsky,Sebastian Kuhn,Janna N. Hauser,Mulugeta Nega,Nagendra N. Mishra,Nagendra N. Mishra,Cordula Gekeler,Arnold S. Bayer,Arnold S. Bayer,Andreas Peschel +11 more
TL;DR: This report characterized the most commonly reported MprF mutations in DAP-R S. aureus strains in a defined genetic background and found that only certain mutations, including the frequently reported T345A single nucleotide polymorphism (SNP), can reproducibly cause daptomycin resistance.
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Inhibition of the ATP Synthase Eliminates the Intrinsic Resistance of Staphylococcus aureus towards Polymyxins.
Martin Vestergaard,Katrine Nøhr-Meldgaard,Martin Saxtorph Bojer,Christina Nielsen,Rikke Louise Meyer,Christoph Slavetinsky,Andreas Peschel,Hanne Ingmer +7 more
TL;DR: By modulation of bacterial metabolism, new classes of antibiotics may show efficacy against pathogens towards which they were previously considered inapplicable, and may pave the way for novel applications of existing antibiotics.
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Alanyl-Phosphatidylglycerol and Lysyl-Phosphatidylglycerol Are Translocated by the Same MprF Flippases and Have Similar Capacities To Protect against the Antibiotic Daptomycin in Staphylococcus aureus
TL;DR: Bacterial aminoacyl phospholipid flippases exhibit more relaxed substrate specificity and Ala-PG and Lys-PG are more similar in their capacities to modulate membrane functions than anticipated.
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Staphylococcus epidermidis clones express Staphylococcus aureus-type wall teichoic acid to shift from a commensal to pathogen lifestyle.
Xin Du,Jesper Larsen,Min Li,Axel Walter,Christoph Slavetinsky,Anna Both,Patricia M Sanchez Carballo,Marc Stegger,Esther Lehmann,Yao Liu,Junlan Liu,Jessica Slavetinsky,Katarzyna A. Duda,Bernhard Krismer,Simon Heilbronner,Christopher Weidenmaier,Christoph Mayer,Holger Rohde,Volker Winstel,Andreas Peschel +19 more
TL;DR: In this paper, a combined epidemiological and functional approach was used to show that while commensal clones express poly-glycerolphosphate WTA, S. epidermidis multilocus sequence type 23, which emerged in the past 15 years and is one of the main infection-causing HA-MRSE clones, contains an accessory genetic element, tarIJLM, that leads to the production of a second, Staphylococcus aureus-type WTA (poly-ribitosphate (RboP)).
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