Christoph Heusser
Novartis
106 Papers
1.5K Citations
Christoph Heusser is an academic researcher from Novartis. The author has contributed to research in topics: Antibody & Immunoglobulin E. The author has an hindex of 36, co-authored 106 publications.
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Papers
Detection of intracellular cytokines by flow cytometry
TL;DR: In this article, the carboxylic ionophore monensin was used to interrupt intracellular transport processes leading to an accumulation of the cytokine in the Golgi complex.
992
Human peripheral blood basophils primed by interleukin 3(IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation
TL;DR: Human basophils are an important cellular source of IL-4, and may, therefore, in addition to their inflammatory effector functions, also regulate the differentiation of T helper cells and B cells, in particular in allergic diseases.
•Journal Article
Effect of Chemical and Enzymatic Radioiodination on in Vitro Human Clq Activities
TL;DR: The hemolytic activity of Clq is quite labile to either low levels of iodide incorporation or the oxidizing conditions of the labeling procedure, and its ability to bind immune complexes is virtually resistant to the levels and conditions of iodination reported here.
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RECEPTORS FOR IgG: SUBCLASS SPECIFICITY OF RECEPTORS ON DIFFERENT MOUSE CELL TYPES AND THE DEFINITION OF TWO DISTINCT RECEPTORS ON A MACROPHAGE CELL LINE*
TL;DR: The variable pattern of reactivity of the macrophage-like cell lines with monomer and aggregated IgG suggested that two distinct receptors for IgG were present: one capable of binding IgG2a and another capable ofbinding all aggregates, and analysis of the inhibitory capacity of different IgG subclasses confirmed this concept.
203
Simultaneous production of interleukin 2, interleukin 4 and interferon-γ by activated human blood lymphocytes
TL;DR: IL 2, IL 4 and IFN‐γ accumulated in the Golgi system, which resulted in a characteristic morphology of the staining, eliminating problems with evaluation of background signals.
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