Christoph Becker-Pauly
University of Kiel
113 Papers
352 Citations
Christoph Becker-Pauly is an academic researcher from University of Kiel. The author has contributed to research in topics: Proteases & Chemistry. The author has an hindex of 28, co-authored 99 publications. Previous affiliations of Christoph Becker-Pauly include Imperial College London & University of Mainz.
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Papers
Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding.
Felix Jäckle,Frederike Schmidt,Rielana Wichert,Philipp Arnold,Johannes Prox,Martin Mangold,Anke Ohler,Claus U. Pietrzik,Tomas Koudelka,Andreas Tholey,Michael Gütschow,Marit Stirnberg,Christoph Becker-Pauly +12 more
TL;DR: It is shown that MT2, but not TMPRSS4 or pancreatic trypsin, is capable of activating full-length meprin β at the cell surface, analysed by specific fluorogenic peptide cleavage assay, Western blotting and confocal laser scanning microscopy (CLSM).
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Metalloprotease Meprinβ in Rat Kidney: Glomerular Localization and Differential Expression in Glomerulonephritis
Beatrice Oneda,Nadège Lods,Daniel Lottaz,Christoph Becker-Pauly,Walter Stöcker,Jeffrey W. Pippin,Maya Huguenin,Daniel Ambort,Hans-Peter Marti,Erwin E. Sterchi +9 more
TL;DR: It is demonstrated that meprinβ is recognized by Fx1A antiserum and may therefore represent an auto-antigen in PHN and suggest a potential involvement in experimental glomerular disease.
Meprinα Transactivates the Epidermal Growth Factor Receptor (EGFR) via Ligand Shedding, thereby Enhancing Colorectal Cancer Cell Proliferation and Migration
TL;DR: Evidence for a meprinα-mediated transactivation of the EGFR signaling pathway is provided and suggest that this mechanism is involved in colorectal cancer progression, and a role for mepr inα in invasion and metastatic dissemination is supported by its pro-angiogenic and pro-migratory activity.
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Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB
Rielana Wichert,Anna Ermund,Stefanie Schmidt,Matthias Schweinlin,Miroslaw Ksiazek,Philipp Arnold,Katharina Knittler,Frederike Wilkens,Barbara Potempa,Björn Rabe,Marit Stirnberg,Ralph Lucius,Jörg W. Bartsch,Susanna Nikolaus,Maren Falk-Paulsen,Philip Rosenstiel,Marco Metzger,Stefan Rose-John,Jan Potempa,Gunnar C. Hansson,Peter J. Dempsey,Christoph Becker-Pauly +21 more
TL;DR: It is demonstrated that meprin β activation and shedding are mutually exclusive events and can be overridden by pathogens, as demonstrated for the bacterial protease Arg-gingipain (RgpB).
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IL-6 trans-signaling in the brain influences the behavioral and physio-pathological phenotype of the Tg2576 and 3xTgAD mouse models of Alzheimer's disease.
Anna Escrig,Carla Canal,Paula Sanchis,Olaya Fernández-Gayol,Alejandro Montilla,Gemma Comes,Amalia Molinero,Mercedes Giralt,Lydia Giménez-Llort,Christoph Becker-Pauly,Stefan Rose-John,Juan Hidalgo +11 more
TL;DR: The results strongly suggest that the inhibition of the IL-6 trans-signaling could represent a powerful therapeutic target in AD.
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