Christine Van Broeckhoven
University of Antwerp
445 Papers
4K Citations
Christine Van Broeckhoven is an academic researcher from University of Antwerp. The author has contributed to research in topics: Biology & Frontotemporal lobar degeneration. The author has an hindex of 99, co-authored 397 publications. Previous affiliations of Christine Van Broeckhoven include University of Graz & Flanders Institute for Biotechnology.
Chat about Author
Papers
Mutated Toll-like receptor 9 increases Alzheimer's disease risk by compromising innate immunity protection.
Rita Cacace,Lujia Zhou,Elisabeth Hendrickx Van de Craen,Arjan Buist,Julie Hoogmartens,Anne Sieben,Patrick Cras,Rik Vandenberghe,Peter Paul De Deyn,Daniel Oehlrich,An De Bondt,Sebastiaan Engelborghs,Diederik Moechars,Christine Van Broeckhoven +13 more
TL;DR: The data suggest a protective role of TLR9 signaling in AD pathogenesis, and it is proposed that TLR 9 loss-of-function may disrupt a peripheral-central immune crosstalk that promotes dampening of inflammation and clearance of toxic protein species, leading to the build-up of neuro inflammation and pathogenic protein aggregates in AD development.
8
Sporadic Creutzfeldt-Jakob Disease and Other Proteinopathies in Comorbidity.
Eva Parobkova,Julie van der Zee,Julie van der Zee,Lubina Dillen,Lubina Dillen,Christine Van Broeckhoven,Christine Van Broeckhoven,Robert Rusina,Radoslav Matej +8 more
TL;DR: A systematic analysis of 15 genes related to the most important neurodegenerative diseases in a cohort of patients with sporadic Creutzfeldt–Jakob disease and sCJD in comorbidity with AD and primary age-related proteinopathy failed to find any critical differences.
Lymphoblast-derived integration-free iPS cell line from a 69-year-old male
Friederike Schröter,Kristel Sleegers,Martina Bohndorf,Wasco Wruck,Christine Van Broeckhoven,James Adjaye +5 more
TL;DR: Human lymphoblast cells were used to generate integration-free induced pluripotent stem cells employing episomal plasmids expressing OCT4, SOX2, NANOG, LIN28, C- MYC and L-MYC.
7