Christine Van Broeckhoven
University of Antwerp
445 Papers
4K Citations
Christine Van Broeckhoven is an academic researcher from University of Antwerp. The author has contributed to research in topics: Biology & Frontotemporal lobar degeneration. The author has an hindex of 99, co-authored 397 publications. Previous affiliations of Christine Van Broeckhoven include University of Graz & Flanders Institute for Biotechnology.
Chat about Author
Papers
Identification and localization of ataxin-7 in brain and retina of a patient with cerebellar ataxia type II using anti-peptide antibody.
Claire Mauger,Jurgen Del-Favero,Chantal Ceuterick,U. Lübke,Christine Van Broeckhoven,Jean-Jacques Martin +5 more
TL;DR: Electron microscopic studies using immunogold labeling showed that ataxin-7 immunoreactive NIs appear as dense aggregates containing a mixture of granular and filamentary structures, and these data confirm the presence of NIs in brain and retina of a SCA7 patient, a common characteristic of disorders caused by expanded CAG/polyGln repeats.
54
Alzheimer-associated C allele of the promoter polymorphism −22C>T causes a critical neuron-specific decrease of presenilin 1 expression
Jessie Theuns,Jacques E. Remacle,Richard Killick,Ellen Corsmit,Krist'l Vennekens,Danny Huylebroeck,Marc Cruts,Christine Van Broeckhoven +7 more
TL;DR: Evidence is provided that the increased risk for AD associated with PSEN1 may result from genetic variations in the regulatory region, leading to altered expression levels of PSEN2 in neurons, including a neuron-specific 2-fold decrease in promoter activity for the -22C risk allele.
Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations
Karolien Bettens,Steven Vermeulen,Caroline Van Cauwenberghe,Bavo Heeman,Bob Asselbergh,Caroline Robberecht,Sebastiaan Engelborghs,Mathieu Vandenbulcke,Rik Vandenberghe,Peter Paul De Deyn,Peter Paul De Deyn,Marc Cruts,Christine Van Broeckhoven,Kristel Sleegers +13 more
TL;DR: Functional analyses suggest reduced secretion of the CLU protein as the mode of action for three patient-specific CLU mutations, possibly interfering with heterodimerization of the α- and β-chain of CLU.
Linkage and Association Studies Identify a Novel Locus for Alzheimer Disease at 7q36 in a Dutch Population-Based Sample
Rosa Rademakers,Marc Cruts,K. Sleegers,K. Sleegers,Bart Dermaut,Jessie Theuns,Yurii S. Aulchenko,Stefan Weckx,Tim De Pooter,Marleen Van den Broeck,Ellen Corsmit,Peter De Rijk,Jurgen Del-Favero,John C. van Swieten,Cornelia M. van Duijn,Cornelia M. van Duijn,Christine Van Broeckhoven +16 more
TL;DR: The linkage data from the informative family 1270 and the association data in the population-based early-onset AD patient-control sample strongly support the identification of a novel AD locus at 7q36 and re-emphasize the genetic heterogeneity of AD.
In vitro studies of Flemish, Dutch, and wild-type beta-amyloid provide evidence for two-staged neurotoxicity.
Samir Kumar-Singh,Ann Julliams,Rony Nuydens,Chantal Ceuterick,Christine Labeur,Sally Serneels,Krist'l Vennekens,Peter Van Osta,Hugo Geerts,Bart De Strooper,Christine Van Broeckhoven +10 more
TL;DR: It is proposed here that, at least in vitro, Abeta might be neurotoxic in an initial phase due to its soluble oligomeric or other early toxic Abeta intermediate(s), which is perhaps distinct from the late neurotoxicity incurred by aggregated larger assemblies of Abeta.
50