Christine Schuberth
University Hospital Bonn
5 Papers
18 Citations
Christine Schuberth is an academic researcher from University Hospital Bonn. The author has contributed to research in topics: Innate immune system & RIG-I. The author has an hindex of 5, co-authored 5 publications.
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Papers
Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates
Delphine Goubau,Martin Schlee,Safia Deddouche,Andrea J. Pruijssers,Thomas Zillinger,Marion Goldeck,Christine Schuberth,Annemarthe G. van der Veen,Tsutomu Fujimura,Jan Rehwinkel,Jason A. Iskarpatyoti,Winfried Barchet,Janos Ludwig,Terence S. Dermody,Gunther Hartmann,Caetano Reis e Sousa +15 more
TL;DR: It is shown that RIG-I also mediates antiviral responses to RNAs bearing 5′-diphosphates (5′pp), indicating that recognition of 5′pp-RNA acts as a powerful means of self/non-self discrimination by the innate immune system.
Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I.
Yanli Wang,Janos Ludwig,Christine Schuberth,Marion Goldeck,Martin Schlee,Haitao Li,Stefan Juranek,Gang Sheng,Ronald Micura,Thomas Tuschl,Gunther Hartmann,Dinshaw J. Patel +11 more
TL;DR: Key intermolecular interactions observed in the crystalline state are retained in the complex of 5′-ppp dsRNA 24-mer and full-length RIG-I under in vivo conditions, as evaluated from the impact of binding pocket Rig-I mutations and 2′-OCH3 RNA modifications on the interferon response.
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RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells.
Cristina Amparo Hagmann,Anna-Maria Herzner,Zeinab Abdullah,Thomas Zillinger,Christopher Jakobs,Christine Schuberth,Christoph Coch,Paul G. Higgins,Hilmar Wisplinghoff,Winfried Barchet,Veit Hornung,Gunther Hartmann,Martin Schlee +12 more
TL;DR: Results show that detection of Listeria RNA by RIG-I represents a non-redundant cytosolic immunorecognition pathway in non-immune cells lacking a functional STING dependent signaling pathway.
Delivery with polycations extends the immunostimulant Ribomunyl into a potent antiviral Toll-like receptor 7/8 agonist.
Stephan Herberhold,Christoph Coch,Thomas Zillinger,Benjamin Hommertgen,Nicolas Busch,Christine Schuberth,Evelyn Hartmann,Vera Wimmenauer,Cristina Amparo Hagmann,Bastian Lüdenbach,Martin Schlee,Friedrich Bootz,Gunther Hartmann,Winfried Barchet +13 more
TL;DR: Ribomunyl is, in principle, able to potently induce antiviral interferon-α and interleukin-12 via TLR7 and TLR8, respectively, but only when formulated in a complex with cationic polypeptides.
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Abstract B44: Selective stimulation of RIG-I with a novel synthetic RNA induces strong anti-tumor immunity in mouse tumor models
Jim Barsoum,Marcel Renn,Christine Schuberth,Christopher Jakobs,Anna Schwickart,Martin Schlee,Jasper van den Boorn,Gunther Hartmann +7 more
TL;DR: A optimized, fully synthetic oligonucleotide, designated RGT100, which is a RIG-I selective ligand shows strong anti-tumor activity in several clinically relevant mouse tumor models, while bearing an advantageous safety profile and is rapidly progressing toward clinical evaluation in cancer patients.
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