Christine Lenoir
French Institute of Health and Medical Research
15 Papers
403 Citations
Christine Lenoir is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Synaptobrevin & Peptide. The author has an hindex of 10, co-authored 15 publications. Previous affiliations of Christine Lenoir include Paris Descartes University.
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Papers
Control of Mitochondrial Membrane Permeabilization by Adenine Nucleotide Translocator Interacting with HIV-1 Viral Protein R and Bcl-2
Etienne Jacotot,Karine F. Ferri,Chahrazed El Hamel,Catherine Brenner,Sabine Druillennec,Johan Hoebeke,Pierre Rustin,Didier Métivier,Christine Lenoir,Maurice Geuskens,Helena L. A. Vieira,Markus Loeffler,Anne-Sophie Belzacq,Jean-Paul Briand,Naoufal Zamzami,Lena Edelman,Zhi Hua Z.H. Xie,John C. Reed,Bernard P. Roques,Guido Kroemer +19 more
TL;DR: It is demonstrated that a synthetic Vpr-derived peptide specifically binds to the intermembrane face of the ANT with an affinity in the nanomolar range, which indicates that both Vpr and Bcl-2 modulate MMP through a direct interaction with ANT.
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High-Throughput Fluorogenic Assay for Determination of Botulinum Type B Neurotoxin Protease Activity
TL;DR: This is the easiest, quickest, and cheapest assay described to date for measuring the proteolytic activity of botulinum type B neurotoxin, and can be easily automated for high-throughput screening.
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Cooperative exosite-dependent cleavage of synaptobrevin by tetanus toxin light chain.
Fabrice Cornille,Loïc Martin,Christine Lenoir,Didier Cussac,Bernard P. Roques,Marie-Claude Fournie-Zaluski +5 more
TL;DR: Results favor an exosite-controlled hydrolysis of synaptobrevin by TeNT, probably involving a conformational change of the toxin, which could account for the high degree of substrate specificity of TeNT and, probably, botulinum neurotoxins.
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A novel short peptide is a specific inhibitor of the human immunodeficiency virus type 1 integrase.
Vaea Richard de Soultrait,Anne Caumont,Vincent Parissi,Nelly Morellet,Michel Ventura,Christine Lenoir,Simon Litvak,Michel Fournier,Bernard P. Roques +8 more
TL;DR: This work isolated a 33-mer peptide that inhibited both in vitro IN activities and showed a significant antiviral effect when assayed on HIV-1 infected human cells, suggesting this potentially important short lead peptide may not only be helpful to design new anti-HIV agents, but also could prove very useful in further studies of the structural and functional characteristics of HIV- 1 IN.
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A Sensitive and Rapid Fluorescence-Based Assay for Determination of Tetanus Toxin Peptidase Activity
J M Soleilhac,Fabrice Cornille,Loïc Martin,Christine Lenoir,Marie-Claude Fournie-Zaluski,Bernard P. Roques +5 more
TL;DR: This novel enzymatic assay, which could be easily extended to other clostridial neurotoxins, is a major improvement in term of sensitivity and time saving, compared to currently used methods (SDS-PAGE, HPLC).
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