Christine L. Mummery
Leiden University Medical Center
451 Papers
4.3K Citations
Christine L. Mummery is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Embryonic stem cell & Stem cell. The author has an hindex of 94, co-authored 416 publications. Previous affiliations of Christine L. Mummery include Loyola University Medical Center & University Medical Center Utrecht.
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Papers
Rapid ionic events and the initiation of growth in serum-stimulated neuroblastoma cells
TL;DR: The results suggest that serum growth factors act, at least in part, by stimulating an electroneutral, amiloride-sensitive Na+/H+ exchange mechanism, which results in the observed stimulation of the Na+, K+ pump, while the simultaneous efflux of protons may raise the intracellular pH.
249
Human Embryonic Stem Cell–Derived Cardiomyocytes and Cardiac Repair in Rodents
TL;DR: The results show that midterm data in these kinds of experiments must be interpreted with caution and longer-term follow-up is essential to draw conclusions on the efficacy of cardiac cell transplantation, and demonstrate the unlikely success of merely generating and injecting more cells of the same type to increase functional improvement.
246
Personalised organs-on-chips: functional testing for precision medicine
Albert van den Berg,Christine L. Mummery,Christine L. Mummery,Robert Passier,Andries D. van der Meer +4 more
TL;DR: Organs-on-chips can be ‘personalised’ so they can be used as functional tests to inform clinical decision-making for specific patients.
Stalk Cell Phenotype Depends on Integration of Notch and Smad1/5 Signaling Cascades
Iván M. Moya,Lieve Umans,Elke Maas,Paulo N. G. Pereira,Karen Beets,Annick Francis,Ward Sents,Elizabeth J. Robertson,Christine L. Mummery,Danny Huylebroeck,An Zwijsen +10 more
TL;DR: In vivo evidence is provided for a regulatory loop between BMP/TGFβ-Smad1/5 and Notch signaling that orchestrates tip- versus stalk-cell selection and vessel plasticity.
227
Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells
Matthew J. Birket,Marcelo C. Ribeiro,Arie O. Verkerk,Dorien Ward,Ana Rita Leitoguinho,Sabine C. Den Hartogh,Valeria V. Orlova,Harsha D. Devalla,Verena Schwach,Milena Bellin,Robert Passier,Christine L. Mummery +11 more
TL;DR: Human pluripotent stem cells bearing a cardiac lineage reporter is used to show that regulated MYC expression enables robust expansion of CPCs with insulin-like growth factor-1 (IGF-1) and a hedgehog pathway agonist.
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