Christine J. Harrison
Newcastle University
383 Papers
3.3K Citations
Christine J. Harrison is an academic researcher from Newcastle University. The author has contributed to research in topics: Medicine & Cytogenetics. The author has an hindex of 73, co-authored 365 publications. Previous affiliations of Christine J. Harrison include University College London & Southampton General Hospital.
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Papers
A Fluorescence in Situ Hybridization Map of 6q Deletions in Acute Lymphocytic Leukemia Identification and Analysis of a Candidate Tumor Suppressor Gene
Paul Sinclair,Amani Sorour,M Martineau,Christine J. Harrison,Wayne A. Mitchell,Elena O’Neill,Letizia Foroni +6 more
TL;DR: Analysis of GRIK2 in 14 ALL cases carrying heterozygous 6q deletions revealed a constitutional and paternally inherited C to G substitution in exon 6 encoding for an amino acid change in one patient, raising the possibility that this gene may be protective against multiple tumor types.
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The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL.
Kim R. Kampen,Sergey O. Sulima,Benno Verbelen,Tiziana Girardi,Stijn Vereecke,Gianmarco Rinaldi,Jelle Verbeeck,Joyce Op de Beeck,Anne Uyttebroeck,Jules P.P. Meijerink,Anthony V. Moorman,Christine J. Harrison,Pieter Spincemaille,Jan Cools,David Cassiman,Sarah-Maria Fendt,Pieter Vermeersch,Kim De Keersmaecker +17 more
TL;DR: The R98S mutation in ribosomal protein L10 affects 8% of pediatric T-cell acute lymphoblastic leukemia cases, and was previously described to impair cellular proliferation, and is revealed to accumulate reactive oxygen species which promotes mitochondrial dysfunction and reduced ATP levels, causing the proliferation defect.
MRC trials in childhood acute myeloid leukaemia.
TL;DR: The current trial MRC AML 15 investigates the role of fludarabine--idarubicin combination therapy in the induction courses and therole of high dose cytarabine during consolidation; the aim being to increase efficacy and reduce toxicity, particularly that involving the heart.
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Variable Breakpoints Target PAX5 in Patients with Dicentric Chromosomes: A Model for the Basis of Unbalanced Translocations in Cancer
Jonathan C. Strefford,Qian An,Sarah L. Wright,Zoe J. Konn,Elizabeth Matherson,Lynne Minto,Anthony V. Moorman,Helen Parker,Andrew G. Hall,Julie Irving,Christine J. Harrison +10 more
TL;DR: It is shown for the first time, that specific gene loci may be the target of heterogeneous breakpoints in human cancer, acting through a variety of mechanisms.
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Validation of the United Kingdom copy-number alteration classifier in 3239 children with B-cell precursor ALL.
Lina Hamadeh,Amir Enshaei,Claire Schwab,Cristina N. Alonso,Andishe Attarbaschi,Gisela Barbany,Monique L. den Boer,Judith M. Boer,Marcin Braun,Luciano Dalla Pozza,Sarah Elitzur,Mariana Emerenciano,Larisa Fechina,Maria S. Felice,Eva Fronkova,Irén Haltrich,Mats Heyman,Keizo Horibe,Toshihiko Imamura,Marta Jeison,Gabor G. Kovacs,Roland P. Kuiper,Wojciech Młynarski,Karin Nebral,Ingegerd Ivanov Öfverholm,Agata Pastorczak,Rob Pieters,Henriett Pikó,Maria S. Pombo-de-Oliveira,Patricia L. Rubio,Sabine Strehl,Jan Stary,Rosemary Sutton,Jan Trka,Grigory Tsaur,Nicola C. Venn,Ajay Vora,Mio Yano,Christine J. Harrison,Anthony V. Moorman +39 more
TL;DR: The UKALL-CNA classifier is a robust prognostic tool that can be deployed in different trial settings and used to refine established cytogenetic risk groups.
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