Christine E. Gee
University of Hamburg
65 Papers
275 Citations
Christine E. Gee is an academic researcher from University of Hamburg. The author has contributed to research in topics: Long-term potentiation & Biology. The author has an hindex of 25, co-authored 54 publications. Previous affiliations of Christine E. Gee include ETH Zurich & Novartis.
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Papers
Two Distinct Signaling Pathways Upregulate NMDA Receptor Responses via Two Distinct Metabotropic Glutamate Receptor Subtypes
TL;DR: One neurotransmitter, glutamate, can activate two distinct and independent signaling systems to target the same effector, and these two pathways are likely to contribute significantly to the highly differentiated control of NMDA receptor function.
Improved methods for marking active neuron populations.
Benjamien Moeyaert,Graham T. Holt,Graham T. Holt,Rajtarun Madangopal,Alberto Perez-Alvarez,Brenna C. Fearey,Nicholas F. Trojanowski,Julia Ledderose,Timothy A. Zolnik,Aniruddha Das,Davina Patel,Timothy A. Brown,Robert N. S. Sachdev,Britta J. Eickholt,Britta J. Eickholt,Matthew E. Larkum,Gina G. Turrigiano,Hod Dana,Hod Dana,Christine E. Gee,Thomas G. Oertner,Bruce T. Hope,Eric R. Schreiter +22 more
TL;DR: CaMPARI2, a photoconvertible fluorescent protein sensor for neuronal activity with improved brightness and calcium binding kinetics, as well as an antibody to amplify the activated sensor signal in fixed samples is developed.
Metabotropic glutamate receptors: intracellular signaling pathways.
TL;DR: Characterization of these novel transduction mechanisms is providing new insights into the roles of metabotropic glutamate receptors in the regulation and modulation of diverse functions in the nervous system.
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Group I metabotropic glutamate receptors activate a calcium-sensitive transient receptor potential-like conductance in rat hippocampus.
TL;DR: This work has found that activation of Gq‐coupled group I metabotropic glutamate receptors (mGluRs) induces a non‐selective cationic conductance that enhances excitability that shares several properties with conductances that are mediated by the transient receptor potential (TRP) family of ion channels.
134
Coincident Pre- and Postsynaptic Activation Induces Dendritic Filopodia via Neurotrypsin-Dependent Agrin Cleavage
Kazumasa Matsumoto-Miyai,Ewa Sokolowska,Andreas Zurlinden,Christine E. Gee,Daniel Lüscher,Stefan Hettwer,Jens Wölfel,Ana Paula Ladner,Jeanne Ster,Urs Gerber,Thomas Rülicke,Beat Kunz,Peter Sonderegger +12 more
TL;DR: The activity-dependent formation of dendritic filopodia is abolished in hippocampal neurons from neurotrypsin-deficient mice and may be instrumental for a Hebbian organization and remodeling of synaptic circuits in the CNS.
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