Christine Bourcier
Centre national de la recherche scientifique
8 Papers
221 Citations
Christine Bourcier is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: MAPK/ERK pathway & Kinase. The author has an hindex of 7, co-authored 8 publications.
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Papers
Distinct signals via Rho GTPases and Src drive shape changes by thrombin and sphingosine-1-phosphate in endothelial cells.
TL;DR: The thrombin-induced contractile and immobile phenotype in endothelial cells reflects both robust RhoA activation and Rac inhibition, whereas Src- and Rac-dependent events couple sphingosine-1-phosphate receptors to the actin polymerizing machinery that drives the extension of lamellipodia and cell migration.
153
Endothelial cells genetically selected from differentiating mouse embryonic stem cells incorporate at sites of neovascularization in vivo.
Sandrine Marchetti,Clotilde Gimond,Kristiina Iljin,Christine Bourcier,Kari Alitalo,Jacques Pouysségur,Gilles Pagès +6 more
TL;DR: Results suggest that application of endothelial lineage selection to differentiating ES cells may become a useful approach for future pro-angiogenic and endothelial cell replacement therapies.
133
Imatinib mesylate (STI571) decreases the vascular endothelial growth factor plasma concentration in patients with chronic myeloid leukemia
Laurence Legros,Christine Bourcier,Arnaud Jacquel,Francois-Xavier Mahon,Cassuto Jp,Patrick Auberger,Gilles Pagès +6 more
TL;DR: The aim of this study was to determine the capacity of imatinib mesylate to modulate one of the most potent regulators of angiogenesis, the vascular endothelial growth factor (VEGF), and to demonstrate the potential prognostic value of VEGF concentrations in evaluating the evolution of CML patients treated with Imatinib.
89
p44 Mitogen-Activated Protein Kinase (Extracellular Signal-Regulated Kinase 1)–Dependent Signaling Contributes to Epithelial Skin Carcinogenesis
Christine Bourcier,Arnaud Jacquel,Jochen Hess,Isabelle Peyrottes,Peter Angel,Paul Hofman,Patrick Auberger,Jacques Pouysségur,Gilles Pagès,Gilles Pagès +9 more
TL;DR: Keratinocytes obtained from knockout mice showed reduced growth and resistance to apoptotic signals, accompanied by an impaired expression of genes implicated in growth control and invasiveness, highlighting the importance of ERK1 in skin homeostasis and in the process of skin tumor development.
85
A synonymous polymorphism of the Tristetraprolin (TTP) gene, an AU-rich mRNA-binding protein, affects translation efficiency and response to Herceptin treatment in breast cancer patients
Paola Griseri,Christine Bourcier,Corinne Hieblot,Khadija Essafi-Benkhadir,Emmanuel Chamorey,Christian Touriol,Gilles Pagès +6 more
TL;DR: Whether TTP correlates with tumor aggressiveness in breast cancer and is a novel prognostic factor for this neoplasia is investigated and a synonymous polymorphism that showed a statistically significant association with a lack of response to Herceptin/Trastuzumab in HER2-positive-breast cancer patients is identified.