Christina M. Bender
University of Southern California
9 Papers
316 Citations
Christina M. Bender is an academic researcher from University of Southern California. The author has contributed to research in topics: Methylation & DNA methylation. The author has an hindex of 9, co-authored 9 publications.
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Papers
Roles of Cell Division and Gene Transcription in the Methylation of CpG Islands
Christina M. Bender,Mark L. Gonzalgo,Felicidad A. Gonzales,Carvell T. Nguyen,Keith D. Robertson,Peter A. Jones +5 more
TL;DR: The data suggest that de novo methylation is not restricted to the S phase of the cell cycle and that transcription through CpG islands does not inhibit theirRemethylation, which occurred most rapidly in the p16, PAX-6, and c-ABL genes, shown to be transcribed prior to drug treatment.
148
•Journal Article
Low frequency of p16/CDKN2A methylation in sporadic melanoma: comparative approaches for methylation analysis of primary tumors.
Mark L. Gonzalgo,Christina M. Bender,Edward H. You,J. Michael Glendening,Flores Jf,Walker Gj,Walker Gj,Nicholas K. Hayward,Peter A. Jones,Jane W. Fountain +9 more
TL;DR: PCR-based techniques can be reliably used for the accurate detection and quantitation of aberrant levels of DNA methylation in tumor specimens, and methylation-associated gene silencing does not represent a common mechanism for p16 inactivation in sporadic melanoma.
Pax6 methylation and ectopic expression in human tumor cells
Carol E. Salem,Isabel D.C. Markl,Christina M. Bender,Felicidad A. Gonzales,Peter A. Jones,Gangning Liang +5 more
TL;DR: E ectopic expression and hypermethylation of exon 5 of PAX6 demonstrate that methylation within a transcribed region, as opposed to promoter methylation, does not block gene expression.
90
DNA Methylation as a Target for Drug Design
TL;DR: The mutagenicity of 5-Methylcytosine (5mC) and the role of promoter hypermethylation in gene silencing, particularly in cancer, suggest a clinical significance for the design of novel DNA methylation inhibitors which may be utilized to reverse the effects ofDNA methylation.
84
•Journal Article
Mismatch Repair Deficiency and CpG Island Hypermethylation in Sporadic Colon Adenocarcinomas
Zhenggang Xiong,Anna H. Wu,Christina M. Bender,Jen-Lan Tsao,Corey Blake,Darryl Shibata,Peter A. Jones,Mimi C. Yu,Ronald Ross,Peter W. Laird +9 more
TL;DR: The results suggest a possible defect in the protection against CpG island hypermethylation shared between CDKN2A and MLH1 and do not support the notion of a functional association between CD KN2A methylation and the phenotype of mismatch repair deficiency.
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