Christian Widmann
University of Lausanne
186 Papers
1.4K Citations
Christian Widmann is an academic researcher from University of Lausanne. The author has contributed to research in topics: Medicine & Apoptosis. The author has an hindex of 43, co-authored 143 publications. Previous affiliations of Christian Widmann include National Jewish Health & Ludwig Institute for Cancer Research.
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Papers
Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
TL;DR: All known MAPK module kinases from yeast to humans are defined, what is known about their regulation, defined MAPK substrates, and the function of MAPK in cell physiology are defined.
2.8K
Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor.
TL;DR: The present data will contribute to the characterization of the receptor binding site and the development of new agonists of this receptor.
627
The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases
TL;DR: It is reported that a DEVD motif-specific caspase that cleaves MEKK-1 specifically is activated when cells lose matrix contact, which activates more caspases activity, comprising a positive feedback loop.
543
Caspase-dependent Cleavage of Signaling Proteins during Apoptosis: A TURN-OFF MECHANISM FOR ANTI-APOPTOTIC SIGNALS
TL;DR: Results indicate that caspase-dependent cleavage of specific proteins induces the turn off of survival pathways, such as the extracellular signal-regulated kinase and phosphatidylinositol-3 kinase/Akt pathways, that could otherwise interfere with the apoptotic response.
456
MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases?
TL;DR: Regulation of the JNK pathway provides an interesting example of how many different stimuli can converge into regulating pathways critical for the determination of cell fate.
356