Christian Weber
Ludwig Maximilian University of Munich
914 Papers
5.9K Citations
Christian Weber is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Medicine & Chemokine. The author has an hindex of 122, co-authored 776 publications. Previous affiliations of Christian Weber include Institute for Geosciences and Natural Resources & University of Kiel.
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Papers
Perivascular Mast Cells Promote Atherogenesis and Induce Plaque Destabilization in Apolipoprotein E–Deficient Mice
Ilize Bot,Saskia C.A. de Jager,Aima Zernecke,Ken A. Lindstedt,Theo J.C. Van Berkel,Christian Weber,Erik A.L. Biessen +6 more
TL;DR: This is the first study to demonstrate that mast cells play a crucial role in plaque progression and destabilization in vivo and propose that mast cell stabilization could be a new therapeutic approach to the prevention of acute coronary syndromes.
302
Ccr5 But Not Ccr1 Deficiency Reduces Development of Diet-Induced Atherosclerosis in Mice
Vincent Braunersreuther,Alma Zernecke,Claire Arnaud,Elisa A. Liehn,Sabine Steffens,Erdenechimeg Shagdarsuren,Kiril Bidzhekov,Fabienne Burger,Graziano Pelli,Bruno Luckow,François Mach,Christian Weber +11 more
TL;DR: Genetic deletion of Ccr5 but not Ccr1 in ApoE−/− mice protects from diet-induced atherosclerosis, associated with a more stable plaque phenotype, reduced mononuclear cell infiltration, Th1-type immune responses, and increased interleukin-10 expression.
299
Statin treatment after onset of sepsis in a murine model improves survival
Marc W. Merx,Elisa A. Liehn,Jürgen Graf,Annette M. van de Sandt,Maren Schaltenbrand,Jürgen Schrader,Peter Hanrath,Christian Weber +7 more
TL;DR: Well established in the treatment of lipid disorders and coronary artery disease, statins harbor the additional and novel potential of effective sepsis treatment, and this benefit extends to several but not all statins tested.
297
Mechanisms underlying neutrophil-mediated monocyte recruitment
TL;DR: It may be more promising to aim at interfering with subsequent PMN-driven proinflammatory events, such as release of inflammation-sustaining cytokines and reactive oxygen species, rather than targeting PMNs without causing serious side effects.
297
Macrophage Migration Inhibitory Factor in Cardiovascular Disease
TL;DR: A synopsis of the involvement of MIF in the inflammatory pathogenesis of atherosclerosis and its consequences, namely unstable plaque formation, remodeling after arterial injury, aneurysm formation, myocardial infarction, or ischemia-reperfusion injury is provided.
289