Christian Weber
Ludwig Maximilian University of Munich
914 Papers
5.9K Citations
Christian Weber is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Medicine & Chemokine. The author has an hindex of 122, co-authored 776 publications. Previous affiliations of Christian Weber include Institute for Geosciences and Natural Resources & University of Kiel.
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Papers
Sepsis and the Heart
Marc W. Merx,Christian Weber +1 more
TL;DR: Some characteristics of septic myocardial dysfunction are delineated, the most commonly cited and reported underlying mechanisms of cardiac dysfunction in sepsis are assessed, and current therapeutic strategies and possible future approaches are outlined.
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Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance
Maria Casanova-Acebes,Christophe Pitaval,Linnea A. Weiss,César Nombela-Arrieta,Raphael Chevre,Noelia A-Gonzalez,Yuya Kunisaki,Dachuan Zhang,Nico van Rooijen,Leslie E. Silberstein,Christian Weber,Takashi Nagasawa,Paul S. Frenette,Antonio Castrillo,Andrés Hidalgo +14 more
TL;DR: It is reported that the homeostatic clearance of neutrophils provides cues that modulate the physiology of the bone marrow and is essential for the rhythmic egress of hematopoietic progenitors into the circulation.
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Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype
Michael Horckmans,Larisa Ring,Johan Duchene,Donato Santovito,Donato Santovito,Maximilian J. Schloss,Maik Drechsler,Christian Weber,Oliver Soehnlein,Sabine Steffens +9 more
TL;DR: Neutrophils are crucially involved in cardiac repair after MI by polarizing macrophages towards a reparative phenotype, andTherapeutic strategies to reduce acute neutrophil-driven inflammation after MI should be carefully balanced as they might interfere with the healing response and cardiac remodelling.
MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1
Andreas Schober,Maliheh Nazari-Jahantigh,Yuanyuan Wei,Kiril Bidzhekov,Felix Gremse,Jochen Grommes,Remco T. A. Megens,Kathrin Heyll,Heidi Noels,Michael Hristov,Shusheng Wang,Fabian Kiessling,Eric N. Olson,Christian Weber +13 more
TL;DR: It is shown that endothelial miR-126-5p maintains a proliferative reserve in ECs through suppression of the Notch1 inhibitor delta-like 1 homolog (Dlk1) and thereby prevents atherosclerotic lesion formation and introduces a potential therapeutic approach.
RANTES Deposition by Platelets Triggers Monocyte Arrest on Inflamed and Atherosclerotic Endothelium
Philipp von Hundelshausen,Philipp von Hundelshausen,Philipp von Hundelshausen,Kim S. C. Weber,Kim S. C. Weber,Kim S. C. Weber,Yuqing Huo,Yuqing Huo,Yuqing Huo,Amanda E. I. Proudfoot,Amanda E. I. Proudfoot,Amanda E. I. Proudfoot,Peter J. Nelson,Peter J. Nelson,Peter J. Nelson,Klaus Ley,Klaus Ley,Klaus Ley,Christian Weber +18 more
TL;DR: The deposition of RANTES by platelets triggers shear-resistant monocyte arrest on inflamed or atherosclerotic endothelium and may epitomize a novel principle relevant to inflammatory or atherogenic monocyte recruitment from the circulation.
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