Christian Studer
Novartis
17 Papers
52 Citations
Christian Studer is an academic researcher from Novartis. The author has contributed to research in topics: Biology & Endoplasmic reticulum. The author has an hindex of 12, co-authored 16 publications.
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Papers
High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions.
Dominic Hoepfner,Stephen B. Helliwell,Heather Sadlish,Sven Schuierer,Ireos Filipuzzi,Sophie Brachat,Bhupinder Bhullar,Uwe Plikat,Yann Abraham,Marc Altorfer,Thomas Aust,Lukas Baeriswyl,Raffaele Cerino,Lena Chang,David Estoppey,Juerg Eichenberger,Mathias Frederiksen,Nicole Hartmann,Annika Hohendahl,Britta Knapp,Philipp Krastel,Nicolas Melin,Florian Nigsch,Edward J. Oakeley,Virginie Petitjean,Frank Petersen,Ralph Riedl,Esther K. Schmitt,Frank Staedtler,Christian Studer,John A. Tallarico,Stefan Wetzel,Mark C. Fishman,Jeffrey A. Porter,N. Rao Movva +34 more
TL;DR: Using an optimized platform, the relative sensitivities of the heterozygous and homozygous deletion collections for nearly 1800 biologically active compounds are provided, providing unique insights into pathways that are sensitive and resistant to a given perturbation.
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Evidence for a functionally relevant rocaglamide binding site on the eIF4A-RNA complex.
Heather Sadlish,Gabriela Galicia-Vázquez,C. Gregory Paris,Thomas Aust,Bhupinder Bhullar,Lena Chang,Stephen B. Helliwell,Dominic Hoepfner,Britta Knapp,Ralph Riedl,Silvio Roggo,Sven Schuierer,Christian Studer,John A. Porco,Jerry Pelletier,N. Rao Movva +15 more
TL;DR: It is demonstrated that the chemically distinct silvestrol and synthetic rocaglamides share a common mechanism of action, which will be critical for optimization of physiologically stable derivatives and confirm the value of the ro caglamide scaffold for exploring the impact of translational modulation on disease.
TORC2 Signaling Pathway Guarantees Genome Stability in the Face of DNA Strand Breaks
Kenji Shimada,Ireos Filipuzzi,Michael Stahl,Stephen B. Helliwell,Christian Studer,Dominic Hoepfner,Andrew Seeber,Andrew Seeber,Robbie Loewith,N. Rao Movva,Susan M. Gasser,Susan M. Gasser +11 more
TL;DR: An inhibitor of target of rapamycin (TOR) complexes 1 and 2 that selectively enhances the sensitivity of sgs1Δ cells to hydroxyurea and camptothecin is identified and implicate TORC2-mediated actin filament regulation in the survival of low levels of DNA damage.
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Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon.
Tina Junne,Joanne Wong,Christian Studer,Thomas Aust,Benedikt W. Bauer,Martin Beibel,Bhupinder Bhullar,Robert Bruccoleri,Jürg Eichenberger,David Estoppey,Nicole Hartmann,Britta Knapp,Philipp Krastel,Nicolas Melin,Edward J. Oakeley,Lukas Oberer,Ralph Riedl,Guglielmo Roma,Sven Schuierer,Frank Petersen,John A. Tallarico,Tom A. Rapoport,Martin Spiess,Dominic Hoepfner,Dominic Hoepfner +24 more
TL;DR: Biochemical analysis confirmed inhibition of protein translocation into the endoplasmic reticulum of both co- and post-translationally translocated substrates by both chemotypes, demonstrating a mechanism independent of a translating ribosome.
69
The viral CC chemokine-binding protein vCCI inhibits monocyte chemoattractant protein-1 activity by masking its CCR2B-binding site.
Craig G. Beck,Christian Studer,Jean-François Zuber,Bénédicte Jachez Demange,Ute Manning,Roman Urfer +5 more
TL;DR: The viral chemokine-binding protein vCCI thus inhibits the biological function of MCP-1 by directly masking its CCR2B receptor-binding site.
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