Christian Hertweck
Leibniz Association
423 Papers
1.8K Citations
Christian Hertweck is an academic researcher from Leibniz Association. The author has contributed to research in topics: Polyketide & Biology. The author has an hindex of 72, co-authored 367 publications. Previous affiliations of Christian Hertweck include Schiller International University & University of Arizona.
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Papers
Alternative Benzoxazole Assembly Discovered in Anaerobic Bacteria Provides Access to Privileged Heterocyclic Scaffold
Therese Horch,Evelyn M. Molloy,Florian Bredy,Veit G. Haensch,Kirstin Scherlach,Kyle L. Dunbar,Jonathan Franke,Christian Hertweck +7 more
TL;DR: An overlooked biosynthetic pathway in anaerobic bacteria (typified in Clostridium cavendishii) is reported that expands the benzoxazole chemical space to meta‐substituted heterocycles and heralds a distribution beyond Actinobacteria.
Burkholderia rhizoxinica sp. nov. and Burkholderia endofungorum sp. nov., bacterial endosymbionts of the plant-pathogenic fungus Rhizopus microsporus.
Laila P. Partida-Martinez,Ingrid Groth,Imke Schmitt,Walter Richter,Martin Roth,Christian Hertweck +5 more
TL;DR: The phylogenetic studies based on 16S rRNA gene sequence data, together with conclusive DNA-DNA reassociation experiments, strongly support the proposal that these strains represent two novel species within the genus Burkholderia.
The Fungal Quorum-Sensing Molecule Farnesol Activates Innate Immune Cells but Suppresses Cellular Adaptive Immunity
Ines Leonhardt,Steffi Spielberg,Michael Weber,Daniela Albrecht-Eckardt,Markus Bläss,Ralf A. Claus,Dagmar Barz,Kirstin Scherlach,Christian Hertweck,Jürgen Löffler,Kerstin Hünniger,Oliver Kurzai +11 more
TL;DR: The data unveil the ability of farnesol to act as a virulence factor of C. albicans by influencing innate immune cells to promote inflammation and mitigating the Th1 response, which is essential for fungal clearance.
A widespread bacterial phenazine forms S-conjugates with biogenic thiols and crosslinks proteins
Daniel Heine,Srividhya Sundaram,Matthias Beudert,K. Martin,Christian Hertweck,Christian Hertweck +5 more
TL;DR: Bacterial phenazines react with diverse biogenic thiols and proteins under radical-forming conditions, revealing new biological roles based on conjugation and crosslinking of proteins.
Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in anaerobic bacteria
TL;DR: It is shown that the presence of RiPP-genes is widespread among anaerobic representatives of the phyla Actinobacteria, Proteobacteria and Firmicutes and that, collectively, anaerobes possess the ability to synthesize a broad variety of different RiPP classes.